Treat Clozapine ( CLZ )-Resistant Schizophrenia Comparing CLZ + Haloperidol vs. CLZ + Electroconvulsive Therapy (ECT)

Not Applicable

Completed

• Conditions: Schizophrenia
• Interventions: Drug: clozapine+haloperidol; Drug: clozapine,electroconvulsive therapy

• Registration Number: NCT00753051
• Lead Sponsor: Khon Kaen University

Brief Summary

Clozapine treatment resistant schizophrenia is still prevalent.The effectiveness of augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive therapy should be determined.This study is a randomized control trial.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2008-09-15
• Study First Submitted QC: 2008-09-15
• Study First Posted: 2008-09-16
• Primary Completion: 2012-03
• Status Verified: 2012-05
• Study Completion: 2012-05
• Last Update Submitted: 2012-05-04
• Last Update Posted: 2012-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

1. schizophrenic patients diagnosed with schedules for clinical assessment in neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10
2. Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage
3. Voluntary to participate the research protocol expressed by signing informed consent form

Exclusion Criteria

1. Patient does not volunteer himself or herself
2. Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate
3. Patient is deaf, blind , dumb to obstruct good communication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1.	clozapine+haloperidol	clozapine as the main agent and it will be adjuncted by haloperidol
2.	clozapine,electroconvulsive therapy	clozapine as the main agent and it will be adjuncted by electroconvulsive therapy

Primary Outcome Measures

Name	Time	Method
PANSS , HAM-D , CGI , AIMS Scores	every 4 weeks for 24 weeks

Trial Locations

Locations (1)

Department of Psychiatry.Faculty of Medicine.KhonKaen University.; 🇹🇭 Muang, KhonKaen, Thailand