Effects of methylphenidate on the developing brain.

Completed

Conditions: Effect of methylphenidate treatment on the outgrowth of the dopaminergic system in children and young adults with attention-deficit hyperactivity disorder.Effect van de behandeling met methylfenidaat op de uitgroei van het dopamine systeem in kinderen en jong volwassenen met ADHD

Registration Number: NL-OMON20266

Lead Sponsor: Academic Medical Center Amsterdam

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

Male outpatients (ages 10-12 and 23-40) newly diagnosed with ADHD as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV, American Psychiatric Association 1994) and as determined by a structured interview: Diagnostic Interview Schedule for Children fourth edition (DISC-IV; Ferdinand et al., 1998) in parents or Diagnostic Interview voor ADHD bij volwassenen (DIVA; Kooij andFrancken, 2010) in adults.

Exclusion Criteria

1. Co-morbid Axis I psychiatric disorders requiring treatment with medication at study entry;

2. Major medical illness, such as a history of epilepsy and traumatic brain injury;

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. phMRI: % change in ASL signal from baseline in response to acute oral MPH challenge before and after 16 weeks of MPH treatment;<br /><br>2. DTI: % change in FA and MD values from baseline after 16 weeks of MPH treatment;<br /><br>3. Resting state fMRI (rs-fMRI): % change in functional connectivity (FC) within specific (DA) neuronal networks;<br /><br>4. % change of above mentioned outcome parameters during treatment vs. baseline and post-treatment.

Secondary Outcome Measures

Name	Time	Method
1. fMRI: % change in task related BOLD signal from baseline;<br /><br>2. Neuropsychological functioning: change in outcome of several well-validated neuropsychological (computer) tasks addressing emotional processing and impulsivity/behavioral inhibition compared to baseline measurements;<br /><br>3. Sleep log and actigraphy: % change from baseline.