Effect of PRP Joint Cavity Combined with Acupoint Injection on Osteoarthritis of Knee Joint
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Visual Analog Scale (VAS) score
研究概览
简要总结
This study collected general data from 90 patients with KOA in the outpatients and ward of Henan Provincial People's Hospital from January 2023 to December 2023 to compare the long-term effects of intra-articular PRP combined with acupoint PRP, intra-articular PRP, and intra-articular HA on symptoms in patients with mild to moderate osteoarthritis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The expected survival period is more than 3 months;
- •The clinical diagnosis was early knee osteoarthritis;
- •Capable of knee injections;
- •chronic joint pain or swelling (> 4 months);
- •It meets the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2021 Edition) , and the X-ray evaluation results meet the Kellgren-Lawrence scale (K-L scale) level I to level III.
排除标准
- •age over 80 years old;
- •K-L classification is greater than Ⅲ grade;
- •Combined with rheumatoid arthritis, severe osteoporosis, tumor, gout, obvious joint deformity and other diseases;
- •Poor compliance, not according to the provisions of treatment;
- •Pregnant and lactating women;
- •Patients voluntarily withdrew from the study;
- •Patients were lost to follow-up due to various reasons during follow-up.
结局指标
主要结局
Visual Analog Scale (VAS) score
时间窗: Assessments will be conducted at weeks 1, 3, 6, and 12 after treatment.
Visual Analog Scale (VAS) score ranging from 1 to 10, with lower scores indicating less pain intensity
Knee Society Score (KSS)
时间窗: Assessments will be conducted at weeks 1, 3, 6, and 12 after treatment.
Knee Society Score (KSS), which consists of five major items totaling 200 points. Higher scores indicate better knee joint function
Western Ontario and McMaster Universities Osteoarthritis Index
时间窗: Assessments will be conducted at 1, 3, 6, and 12 months after treatment.
The severity of knee osteoarthritis was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, consisting of 24 items with a total possible score of 240 points. Lower WOMAC scores indicate less severe knee osteoarthritis.
次要结局
未报告次要终点