Indicators for the Metabolic Syndrome as Well as the Influence of Different Gen-polymorphs on Weightloss and the Maintenance of Lower Weight Among Children in Treatment for Overweight
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 517
- 试验地点
- 1
- 主要终点
- weightloss
研究概览
简要总结
Definition:
the overall objective is to examine childhood obesity with focus on NAFLD and its treatment. Further, we aimed to investigate the impact of genetic variation on obesity.
The specific aims are to;
- describe the degree of NAFLD among overweight and obese, Danish children. (hypothesis; the degree for pediatric NAFLD among Danish Children was equal that found in other Caucasian paediatric study populations).
- investigate the effect of a multidisciplinary intervention treatment of 1 year on liver fat content.
(hypothesis; the intervention could reduce the liver fat percentage and a reduction in BMI SDS would associate with a reduction in liver fat content) - Analyze changes in liver fat content in relation to changes in levels of fasting blood variables to see if any of them could be used as a clinical tool for monitoring hepatic steatosis in the clinic.
(hypothesis; serum aminotransferases (separately and their ratio, respectively), serum insulin, and HOMA-IR could predict improvement in liver fat content
- Investigate the association between genetic variants and obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •5- 20 Years old.
- •Adipose. BMI > 90 % percentile
- •New patient in the Children's Obesity Clinic, Paediatric Department, University Hospital Holbaek,Region Zealand, Denmark
- •Informed Consent
排除标准
- •Drop-outs
结局指标
主要结局
weightloss
时间窗: 1 Year
次要结局
- NAFLD (non-alcoholic Fatty Liver Disease).Gene-polymorphs(1 Year)
研究者
Jens-Christian Holm
MD, Ph.D.
Zealand University Hospital