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Clinical Trials/NCT06174272
NCT06174272
Recruiting
Not Applicable

Transitional Care Program vs Standard of Care in Cirrhosis With Volume Overload: A Pilot Study

Milton S. Hershey Medical Center1 site in 1 country20 target enrollmentFebruary 15, 2025

Overview

Phase
Not Applicable
Intervention
Transitional Care Program
Conditions
Cirrhosis, Liver
Sponsor
Milton S. Hershey Medical Center
Enrollment
20
Locations
1
Primary Endpoint
Number of instances of weight monitoring
Status
Recruiting
Last Updated
last month

Overview

Brief Summary

The goal of this clinical trial is to learn about an intensive monitoring plan (transitional care program) in patients with cirrhosis and excessive swelling that are going to be discharged from the hospital.

The main question[s] it aims to answer are:

  • How much time and what resources are needed to run such a program
  • How well do patients follow up with the phone calls, bloodwork, and doctor appointments?
  • Do the patients enrolled in the program have less need for hospitalization later, less kidney injury, better fluid control, and/or better survival compared to patients that are not in the program?

Participants will

  • Be given a digital scale and a binder with educational material and a log to monitor their weights after discharge from the hospital
  • Receive a phone call from the study team within 72 hours of discharge and weekly
  • Be given a follow up appointment with hepatology within 4 weeks of discharge

Researchers will compare participants in this program to patients that receive normal care to see if there are differences in need for hospitalization later, kidney injury, fluid control, and/or survival.

Registry
clinicaltrials.gov
Start Date
February 15, 2025
End Date
June 1, 2027
Last Updated
last month
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Karen Krok

Professor of Medicine

Milton S. Hershey Medical Center

Eligibility Criteria

Inclusion Criteria

  • Patients \> 18 years of age.
  • Inpatient at Penn State Health, Milton S. Hershey Medical Center.
  • Diagnosis of cirrhosis.
  • Hospitalized with fluid overload (ascites and/or significant anasarca/edema) requiring diuretic therapy.
  • English speaking

Exclusion Criteria

  • Placement of a TIPS.
  • Ascites from an etiology other than cirrhosis, such as malignancy, heart failure, pancreatitis, nephrotic syndrome.
  • Non-English speaking

Arms & Interventions

Transitional Care Program

Participants will receive a digital scale and monitoring log, educational material, a phone call within 72 hours of discharge and weekly for 8 weeks, and a follow up appointment with a hepatologist within 4 weeks of discharge.

Intervention: Transitional Care Program

Standard of Care

Participants will be given typical discharge and follow up instructions.

Outcomes

Primary Outcomes

Number of instances of weight monitoring

Time Frame: 8 weeks for each participant

at home monitoring weight

feasibility of the program

Time Frame: all 8 weeks of each participant

how much time does it take to review material and complete phone calls

Number of follow up visits

Time Frame: 8 weeks for each participant

lab visits, primary care visits, hepatology visits

Number of successful phone calls

Time Frame: 8 weeks for each participant

weekly phone call with participant

Secondary Outcomes

  • Number of subjects that develop Acute Kidney Injury(12 months)
  • Number of Hospitalizations per participant(12 months)
  • Number of subjects that continue to have volume overload(12 months)
  • Number of subjects that expire(12 months)

Study Sites (1)

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