Comparison of Small Colorectal Polyp Removal Using Cold Endoscopic Mucosal Resection With Hot Endoscopic Mucosal Resection: a Pilot Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Locations
- 2
- Primary Endpoint
- Complete removal of the colorectal polyp
Study Overview
Brief Summary
This study evaluates the efficacy of small colorectal polyp removal using cold endoscopic mucosal resection with hot endoscopic mucosal resection. Half of the participants will receive cold endoscopic mucosal resection, while the other half will receive hot endoscopic mucosal resection.
Detailed Description
Colorectal polyps are considered as precancerous lesions and endoscopical resection is currently the treatment of choice when it is possible.
Colorectal polyps are classified into diminutive polyps (<5mm in diameter), small polyps (6-9mm in diameter), and large polyps (>1cm in diameter). There are several endoscopical treatment methods: cold biopsy forceps polypectomy, cold snare polypectomy, hot biopsy forceps polypectomy, hot snare polypectomy, and endoscopic mucosal resection. Cold polypectomy means mechanical removal of the polyp with snare or biopsy forceps without the use of electrocautery, and hot polypectomy means removal of the polyp with the use of electocautery.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with colorectal polyps that are <1cm in diameter who need endoscopic mucosal resection.
- •Patients who gave informed consents to this study.
Exclusion Criteria
- •Patients under the age of 19
- •Patients who are receiving antiplatelet or anticoagulant therapies
- •Patients with hypercoagulability (i.e., liver cirrhosis, hemophilia, end-stage renal disease, or chronic kidney disease)
Arms & Interventions
Cold EMR group
Patients who have small colorectal polyps (<1cm) who receive endoscopic mucosal resection using snare without electrocautery.
Intervention: Cold endoscopic mucosal resection (Procedure)
Hot EMR group
Patients who have small colorectal polyps (<1cm) who receive endoscopic mucosal resection using snare with the use of electrocautery.
Intervention: Hot endoscopic mucosal resection (Procedure)
Outcomes
Primary Outcomes
Complete removal of the colorectal polyp
Time Frame: At the time of the procedure (endoscopic mucosal resection)
The resected specimen will be reviewed microscopically to assess complete resection including the lateral and base margins
Secondary Outcomes
- Procedure time(At the time of the procedure (endoscopic mucosal resection))
- Complication after endoscopic mucosal resection(Within 1 month)
Investigators
Chang Hwan Park
Professor
Chonnam National University Hospital