Effects of a bio-active yogurt in postmenopausal wome

Not Applicable

Completed

• Conditions: Inflammation; menopause; Diet and Nutrition - Other diet and nutrition disorders; Reproductive Health and Childbirth - Menstruation and menopause; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12620001002976
• Lead Sponsor: Riddet Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-10-06
• Study Completion: 2021-05-31
• Last Update Posted: 14 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 16

Inclusion Criteria

• Women who have been menopausal for at least a year (defined as more than 12 months of consecutive amenorrhea)
• Aged between 45 and 65
• BMI between 25-40Kg/m2

Exclusion Criteria

• Cigarette smokers
• Are on hormone replacement therapy
• Dairy intolerant
• Suffering from inflammatory illnesses including cancer, HIV/Aids or inflammatory bowel disease
• Recently donated blood or have fear of needles
• Are dieting or have any eating disorders and have lost more than 20 Kg weight in the last 6 months
• Have dislike, intolerance or allergy to yoghurt, coconut, coffee or curry
• Have a history of congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft, or
atherosclerosis
• Have a history of cancer, diabetes, hypertension, high cholesterol
• Have a history of gastrointestinal disorder or liver disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma Tumor Necrosis Factor (TNF)– a) using ELISA[Visit 1 (both arms): Baseline and 14 days post yogurt consumption Visit 2 (both arms): Baseline and 30 minutes, 1, 2, 3 and 4 hours post yogurt consumption]

Secondary Outcome Measures

Name	Time	Method
Plasma IL6 (using ELISA)[Visit 1 (both arms): Baseline and 14 days post yogurt consumption Visit 2 (both arms): Baseline and 30 minutes, 1, 2, 3 and 4 hours post yogurt consumption<br>];Plasma glucose (blood test)[Visit 1 (both arms): Baseline and 14 days post yogurt consumption<br>Visit 2 (both arms): Baseline and 30 minutes, 1, 2 and 3 hours post yogurt consumption];Plasma insulin (blood test)[Visit 1 (both arms): Baseline and 14 days post yogurt consumption<br>Visit 2 (both arms): Baseline and 30 minutes, 1, 2 and 3 hours post yogurt consumption];Plasma Triglycerides (blood test)[Visit 1 (both arms): Baseline and 14 days post yogurt consumption Visit 2 (both arms): Baseline and 30 minutes, 1, 2, 3 and 4 hours post yogurt consumption];Blood cholesterol (blood test) composite of fasting cholesterol, LDL-C and HDL-C[Visit 1 (both arms): Baseline and 14 days post yogurt consumption Visit 2 (both arms): Baseline and 30 minutes, 1, 2, 3 and 4 hours post yogurt consumption]