NL-OMON41298
Completed
Not Applicable
The cardiac contribution to cerebral perfusion - 'the heart-brain axis' - Cardiac contribution to cerebral perfusion
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- circulation
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 86
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\* Age between 18 to 30 years (younger subjects), age between 50 to 60 years (older subjects) or age 75 years and older (old subjects)
Exclusion Criteria
- •\* Frail elderly (presence of \*3 criteria: weight loss, weakness, poor endurance/exhaustion, slowness, low physical activity)
- •\* Medical history of CV disease, hypertension, diabetes mellitus, pulmonary disease, neurological disease, malignant disease and/or venous insufficiency
- •\* Abnormal lab results (medical screening)
- •\* Stenosis of (one of) the carotid arteries (retrospectively)
- •\* Abnormal ECG (medical screening)
- •\* Use of systemic medication
- •\* Any cognitive impairment (MMSE\>24 points)
- •\* Contraindication to MRI exposure
Outcomes
Primary Outcomes
Not specified
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