The relation between muscle function and muscle pain in patients with chronic myeloid leukemia (CML): a pilot study

Completed

• Conditions: The relation between muscle function and muscle pain in CML patients on TKIs; TKI-induced myopathy; 10028302

• Registration Number: NL-OMON43129
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-11-24
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

age: >18 years old
CML patient using any TKI (group 1 and 2)
mentally able/ allowed to give informed consent

Exclusion Criteria

known hereditary muscle defect
medication known to cause muscle pain (statins, antidepressiva, antipsychotica, thyroid hormones)
evident prolonged QTc interval (>500 msec)
contra-indication for maximal aerobic exercise test or muscle biopsy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Muscle function (= muscle force, contractile speed, relaxation, and<br /><br>fatigability)<br /><br>muscle energy metabolism (=ATP production rate, activity of mitochondrial<br /><br>respiratory complexes, citrate synthase activity)<br /><br>Cardiorespiratory fitness and anaerobic threshold (during incremental cycling<br /><br>test)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Questionnaires on muscle complaints, fatigability and quality of life<br /><br>(short-form McGill pain questionnaire, and short-form Brief Fatigue Inventory,<br /><br>and short-form 36)<br /><br>* Blood parameters</p><br>