Intra-articular Platelet Rich Plasma vs. Corticosteroid vs. Hyaluronic Acid in the Treatment of Mild and Moderate Osteoarthritis of knee
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Assessment of pain relief by the Visual Analogue Score (VAS).
研究概览
简要总结
A total of 105 patients of age group between 45-75 of both genders will be assessed on the basis of kellgren Lawrence classification of osteoarthritis of knee. Patients will be divided into 3 groups . First group will be receiving 6 ml of rich autologous platelet rich plasma , Second group will receive 40mg of Triamcinilone Acetonide injection , Third group will receive 6 ml of Hyaluronic acid, all into the medial joint space of the knee under sterile aseptic conditions. Variations in VAS scoring system will be the primary outcome where 0 - no pain and 10- worst pain. Variations in the WOMAC scores will be the secondary outcomes where the patients daily activities of living will be scored based on their tolerance , 0 giving the best outcome and 96 giving the worst outcome. Data collection will be done by observation and various parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 45.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient having old to moderate osteoarthritis of knee (kellgran lawrence classification grades 1,2,&3) .
- •All patients above the age of 45 years.
排除标准
- •Patients having secondary osteoarthritis of knee, having history of any previous knee surgeries for ligaments injuries / intra articular fractures.
- •Any history of infections like TB/bacterial (post Septic Sequelae ).
结局指标
主要结局
Assessment of pain relief by the Visual Analogue Score (VAS).
时间窗: 1 month, 3months, 6 months, 12 months.
Where 0 points equal to no pain and 10 points equal to worst pain
时间窗: 1 month, 3months, 6 months, 12 months.
次要结局
- Variations in the WOMAC scores ( Western Ontario and McMaster Universities Arthritis Index )(Where 0 points gives the best outcome and 96 points gives the worst outcome)
研究者
Dr Anooj Pravin Chheda
SRM Institute of Science and Technology