Prehabilitation for Adults With End Stage Renal Disease on the Kidney Transplant Waitlist
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Post kidney transplant mortality
Study Overview
Brief Summary
This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of transplantation.
Detailed Description
Prehabilitation is the enhancement of functional capacity of a patient to improve their ability to withstand a future stressor. The investigators primary objective is to demonstrate feasibility for prehabilitation in Aim 1 and test whether the number of prehabilitation sessions is associated with increased physical activity. The investigators will formally test whether prehabilitation is associated with a reduction in short term and long term KT outcomes as part of Aim 2. The investigators will test whether there is an effect of prehabilitation on short-term (KT length of stay> 2 weeks, early hospital readmission and delayed graft function) and long-term (acute rejection (within the first year), 1 year patient and graft survival) outcomes compared to standard of care controls. Participants will be followed for 3-6 months or until they receive a kidney transplant.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Men and women with end stage renal disease who are within 3-6 months of kidney transplantation and are on the kidney transplant waitlist at Johns Hopkins
- •Must be at least 18 years or older at enrollment
- •Must be English speaking
- •Must be enrolled in an ongoing cohort study of adults with ESRD who are being evaluated for kidney transplantation
- •Must be willing to participate in a prehabilitation program and able to give informed consent
Exclusion Criteria
- •Patients who have any of the following medical conditions will be excluded from the study:
- •Active Angina pectoris
- •Chronic lung disease and daily use of oxygen
- •Cerebral vascular disease
- •Musculoskeletal conditions that would limit participation in prehabilitation
- •Lower- or upper-extremity amputation
- •Orthopedic disorders exacerbated by physical activity
- •Decreased mental capacity
- •Patients who live outside of Maryland will not be included in the study.
Arms & Interventions
Prehabilitation
Intervention: Prehabilitation (Other)
Outcomes
Primary Outcomes
Post kidney transplant mortality
Time Frame: 1 year
1 year patient survival
Secondary Outcomes
No secondary outcomes reported