Relative Oral Bioavailability of GABA From Tomatoes
- Conditions
- GABA Plasmakinetics
- Interventions
- Dietary Supplement: TomatoDietary Supplement: Glutamate supplementDietary Supplement: GABA supplement
- Registration Number
- NCT04086108
- Lead Sponsor
- Wageningen University
- Brief Summary
In this four-way crossover study, a plasmakinetic profile of GABA from tomatoes as compared to a gamma-aminobutyric acid (GABA) supplement in healthy young men will be established. In addition, a plasmakinetic profiles of glutamate from a supplement and from tomatoes as well as the effects of glutamate from tomatoes and a supplement on the GABA plasma levels will be determined. This study will therefore provide information about the effect of a food matrix on GABA plasmakinetics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
- BMI between 18.5 and 25 kg/m2
- Age is between 18 and 28 years
- Good general health
- Male
- Veins suitable for blood sampling
- Able to speak Dutch
- Is currently suffering from a disease including mental disorders
- Has had any gastrointestinal condition/disease within the 3 months prior to the intervention
- Haemoglobin (Hb) level < 8.5 mmol/L
- Has used medication in the two months before and/or during the intervention. Occasional use of NSAIDs or paracetamol (<once a week on average) are is allowed.
- Reported weight loss or weight gain of > 2 kg in the month prior to the intervention
- Use of dietary supplements, 3 weeks before-, or during the intervention.
- Allergic to products that are provided as part of the standardised diet
- Unwilling to consume the products that are part of the standardised diet
- Allergic to tomatoes
- (History of) drug abuse, in this case meaning >1 x per month use of recreational drugs
- Smoking
- Alcohol consumption of >10 standardised glasses per week.
- Not able to refrain from alcohol consumption 2 days before each test day
- Recent or planned blood donation (<3 month prior to first study day or during intervention)
- Personnel of Wageningen University, department of Human Nutrition and Health,
- Currently participating in other research or was participating in another study within 1 month of the intervention or within 3 months if invasive procedures were used.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Tomato Tomato Single oral administration Glutamate supplement Glutamate supplement Single oral administration GABA supplement GABA supplement Single oral administration
- Primary Outcome Measures
Name Time Method Half-life (T1/2) of plasma-time curves of GABA 6 months After intake of a GABA supplement and tomatoes.
Area under the plasma concentration versus time curve (AUC ) of plasma-time curves of GABA 6 months After intake of a GABA supplement and tomatoes.
Peak Plasma Concentration (Cmax) of plasma-time curves of GABA 6 months After intake of a GABA supplement and tomatoes.
Time to Peak Plasma Concentration (Tmax) of plasma-time curves of GABA 6 months After intake of a GABA supplement and tomatoes.
- Secondary Outcome Measures
Name Time Method Time to Peak Plasma Concentration (Tmax) of plasma-time curves of glutamate 6 months After intake of a glutamate supplement and tomatoes
Half-life (T1/2) of plasma-time curves of GABA in response to a glutamate supplement. 6 months This will be compared to the plasma time-curves of GABA after tomato intake.
Area under the plasma concentration versus time curve (AUC) AUC of plasma-time curves of GABA in response to a glutamate supplement. 6 months This will be compared to the plasma time-curves of GABA after tomato intake.
Peak Plasma Concentration (Cmax) of plasma-time curves of GABA in response to a glutamate supplement. 6 months This will be compared to the plasma time-curves of GABA after tomato intake.
Peak Plasma Concentration (Cmax) of plasma-time curves of glutamate 6 months After intake of a glutamate supplement and tomatoes
Area under the plasma concentration versus time curve (AUC) of plasma-time curves of glutamate 6 months After intake of a glutamate supplement and tomatoes
Half-life (T1/2) of plasma-time curves of glutamate 6 months After intake of a glutamate supplement and tomatoes
Time to Peak Plasma Concentration (Tmax) of plasma-time curves of GABA in response to a glutamate supplement. 6 months This will be compared to the plasma time-curves of GABA after tomato intake.
Trial Locations
- Locations (1)
Wageningen University, Division of Human Nutrition
🇳🇱Wageningen, Netherlands