Comparing different doses of dexmedetomidine in attenuating extubation response in controlled hypertensive patients for surgeries under general anaesthesia
- Conditions
- Health Condition 1: null- controlled hypertensive patients undergoing surgery under general anesthesiaHealth Condition 2: I10- Essential (primary) hypertension
- Registration Number
- CTRI/2017/08/009486
- Lead Sponsor
- Dr Rajendra Prasad Government Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
1.Controlled hypertensive patients on antihypertensive drugs for surgery under general anaesthesia
2. American society of Anesthesiologist physical status II
3. Body Mass Index is under 30 Kg/m2
1. Untreated hypertension
2. Users of ACE inhibitors as antihypertensive therapy
3. History of severe cardiovascular disease, renal disease, diabetes mellitus, cerebrovascular disease.
4. Known hypersensitivity to the drug.
5. Difficult airway
6. Any patient who receives blood transfusion.
7. Patients refusal for participation in the study.
8.Patients with ischaemic and/or congestive cardiac disease or abnormal electrocardiography.
9. Patients on digoxin, anticonvulsant or psychotropic medicines.
10. If bradycardia (heart rate < 50/min) or hypotension (systolic blood pressure < 80 mm of Hg) occurs anytime during study period, patient will be excluded from the study.
11. If bispectral index (BIS) > 60 anytime between starting of infusion and extubation, patient to be excluded from the study.
12. If systolic blood pressure >180 mm of Hg during study period.
13.If surgery is not completed within 10 mintues of starting infusion.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a study for evaluating different doses of dexmedetomidine in attenuating extubation response in controlled hypertensive patients for surgeries under general anaesthesia. <br/ ><br> <br/ ><br>Timepoint: hemodynamic response every 30 seconds till 5 min and thereafter every 15 min till 2 hours. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method .Pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), oxygen saturation (SpO2) and bispectral index (BIS) <br/ ><br>.Extubation time will be noted and extubation quality <br/ ><br>.Sedation will be evaluated using Ramsay Sedation Scale <br/ ><br>.Any side effects in form of postoperative nausea, vomiting and bradycardiaTimepoint: extubation quality for a period of 15 min post extubation, sedation 5 minute interval uptill 30 min and thereafter at 30 min interval for next 90 minutes and side effects