Prediction Model of the Blood Pressure Response to the Administration of Fluids in Abdominal Surgery Using the Pram Method.
试验速览
- 阶段
- 不适用
- 入组人数
- 320
- 主要终点
- Dynamic elastacy ratio PPV/SVV
研究概览
简要总结
Fluid therapy is considered a first-line therapy in resuscitation protocols for hemodynamically unstable patients. The administration of fluids usually translates into an increase in Cardiac Output. However, not all patients increase mean blood pressure after fluid administration.
To determine if fluids the administration improves blood pressure, it is necessary to evaluate the dependence of preload, vasomotor tone, and left ventricular stroke volume.
The aim of this study is to confirm the usefulness of dynamic elastance, cardiovascular impedance, cardiac cycle efficiency, and other hemodynamic parameters calculated with the PRAM method as predictors of blood pressure response after fluid administration in open abdominal surgery. This will allow us to make and evaluate a predictive model for the blood pressure response after fluid administration in open abdominal surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients ≥ 18 years
- •Patients scheduled for open abdominal surgery lasting ≥ 120 minutes under general anesthesia with mechanical ventilation and the use of VT of 8 ml / kg ideal weight and who require serious arterial monitoring.
排除标准
- •Patients <18 years.
- •Patients> 80 years.
- •Pregnant women.
- •Urgent surgery.
- •Pathologies that may alter the quality of the arterial signal due to alterations of the dicrotic incisura.
- •Poor quality of the arterial pressure wave due to artifacts of the transduction system (resonance and damping).
- •Personal history of:
- •Cardiac arrhythmia.
- •Left ventricular ejection fraction <30%
- •Right ventricular dysfunction (peak systolic tricuspid annulus velocity <0.16 m / sec)
- •Intracardiac shunt
- •Preoperative creatinine> 1.4 mg / dl.
- •Previous treatment with beta-blockers
结局指标
主要结局
Dynamic elastacy ratio PPV/SVV
时间窗: During surgery
PPV/SVV
次要结局
未报告次要终点
研究者
Oscar Diaz-Cambronero
Anesthetist
Hospital Universitario La Fe
