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临床试验/NCT04594174
NCT04594174Unknown不适用

Prediction Model of the Blood Pressure Response to the Administration of Fluids in Abdominal Surgery Using the Pram Method.

Hospital Universitario La Fe0 个研究点目标入组 320 人开始时间: 2020年11月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
320
主要终点
Dynamic elastacy ratio PPV/SVV

研究概览

简要总结

Fluid therapy is considered a first-line therapy in resuscitation protocols for hemodynamically unstable patients. The administration of fluids usually translates into an increase in Cardiac Output. However, not all patients increase mean blood pressure after fluid administration.

To determine if fluids the administration improves blood pressure, it is necessary to evaluate the dependence of preload, vasomotor tone, and left ventricular stroke volume.

The aim of this study is to confirm the usefulness of dynamic elastance, cardiovascular impedance, cardiac cycle efficiency, and other hemodynamic parameters calculated with the PRAM method as predictors of blood pressure response after fluid administration in open abdominal surgery. This will allow us to make and evaluate a predictive model for the blood pressure response after fluid administration in open abdominal surgery.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients ≥ 18 years
  • Patients scheduled for open abdominal surgery lasting ≥ 120 minutes under general anesthesia with mechanical ventilation and the use of VT of 8 ml / kg ideal weight and who require serious arterial monitoring.

排除标准

  • Patients <18 years.
  • Patients> 80 years.
  • Pregnant women.
  • Urgent surgery.
  • Pathologies that may alter the quality of the arterial signal due to alterations of the dicrotic incisura.
  • Poor quality of the arterial pressure wave due to artifacts of the transduction system (resonance and damping).
  • Personal history of:
  • Cardiac arrhythmia.
  • Left ventricular ejection fraction <30%
  • Right ventricular dysfunction (peak systolic tricuspid annulus velocity <0.16 m / sec)
  • Intracardiac shunt
  • Preoperative creatinine> 1.4 mg / dl.
  • Previous treatment with beta-blockers

结局指标

主要结局

Dynamic elastacy ratio PPV/SVV

时间窗: During surgery

PPV/SVV

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Oscar Diaz-Cambronero

Anesthetist

Hospital Universitario La Fe

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