Differences in Immune Status and Fecal SCFA Between Indonesian Stunted Children and Children With Normal Nutritional Status
概览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Bina Nusantara University
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- IL -10
概览
简要总结
- Type and Research Design A cross-sectional study design with a quantitative approach will be conducted. Cross-sectional research design is one-time research to find a relationship between the independent variable (risk factor) and the dependent variable (effect).
- Time and Location of Research The research will be conducted for approximately six months in 2020 at Banten Regency (namely Tegal Ongok and Pasirkarang) and Sumedang Regency.
- Population and Research Sample The population is children between three and five years old in the village of stunting locus.
The sampling method to be used in this research was quota sampling, namely 50 stunting and 50 healthy children from each Regency.
详细描述
The variables studied will be the nutritional status of children between three and five years old, the characteristics of these children (age, sex, LBW, birth length, history of immunization, history of diarrhea, history of upper respiratory tract infection, food intake), mother and family characteristics (mother's age, mother's education, mother's occupation, father's occupation), home environment (aspects of the components of the house, aspects of sanitation facilities, aspects of occupant behavior), the composition of the intestinal microbiota. Data will be obtained through measurements, interviews using a questionnaire, and direct observation using a checklist.
Stunting anthropometric measurements are measured based on parameters of length/height according to age compared to the WHO anthropometric standards 2005 and the Indonesian Minister of Health Decree No. 1995 / MENKES / SK / XII / 2010.
The nutritional status of each child included in this study will be quantified using the WHO recommended three nutritional Z-scores namely, height for age (referred to in this study as Zscore
- weight for age (referred as Z-score
- and weight for height (referred as Z-score
- .A structured questionnaire was used for face-to-face interviews with the respective child mother to collect sociodemographic information. In addition, age and anthropometric measurements (height, weight) based on the Department of Health Ministry of Indonesia The regulation will be recorded. For stunting, the thresholds for height-for-age are: 'severely stunted' (<-3 SD); 'stunted' (-3 SD to < -2 SD); 'normal' (-2 SD to +3 SD); 'tall' (> +3 SD). Furthermore, in order to obtain an overall measure of the nutritional status of these children, the children will be classified into weight-for-height categories: 'severely wasted' (<-3 SD); 'wasted' (-3 SD to < -2 SD); 'normal' (-2 SD to +1 SD); 'possible risk of overweight' (+1 SD to +2 SD); 'overweight' (> +2 SD to +3 SD); 'obese' (> +3 SD)
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 3 Years 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children age : 3 - 5 years old (36-60 months)
- •Live in the research area
- •Apparently healthy children, after examination by a physician
- •Involved in a research study (informed consent signed by parent or guardian)
排除标准
- •Children age \< 36 month and \> 60 month
- •Live outside research area
- •Unhealthy, after examination by a physician
结局指标
主要结局
IL -10
时间窗: 1 week analysis
unit pg/ml from serum
TNF alfa
时间窗: 1 week analysis
unit pg/mL from serum
TGF beta
时间窗: 1 week analysis
Unit : pg/mL from serum
sIgA
时间窗: 1 week analysis
Unit : ul/ml from feses extract
LBP
时间窗: 1 week analysis
Unit ul/ml from serum
次要结局
- Short Chain Fatty Acid(1 months)
研究者
Ingrid S Surono
Principal Investigator
Bina Nusantara University