eutrophil granulocyte membrane-based biomarker discovery for discrimination between acute bacterial versus acute viral infection: a pilot study.
- Conditions
- Bacterial and viral respiratory infections10019815
- Registration Number
- NL-OMON49203
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 44
Patients: Adult (18 or above) participants with a suspected respiratory tract
infection (pneumonia defined as respiratory complaints) presenting with fever
(Temperature >37.7), at the Leiden University Medical Center, who will be
admitted to the hospital, mentally competent., Healthy controls: adult (18 or
above), temperature <37.5, no suspected infection
Relation with the PI or the relevant department
The participant is under treatment of immunosuppressive agents and/or
antihistamines
The participant is treated with chemotherapeutics
The participant is treated with intravenous medication
The participant has leukopenia (<2.5 leukocyten x10^9/L)
The participant has used antibiotics (one or more tablets, in the past 48 hours
or chronically)
Participants who are on corticosteroid treatment (inhalers included)
Participants who suffer or have suffered from diseases affecting bone marrow
functio or after stem cell transplantation
Hemato-oncologic patients
Terminal patients (prognosis <6 months)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Membrane bound proteins (biomarkers) on neutrophils and CD64 expressing cells.<br /><br>(spectrum of proteins as determined by proteomics)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Analysis of previously studied serum markers CRP and IP-10 using a rapid Point<br /><br>of Care (POC) lateral flow test and multiplex cytokine analysis</p><br>