Search for a Recanalization of the Sylvian Artery Electro-Physiological Biomarker

Recruiting

• Conditions: AIS

• Registration Number: NCT05473975
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Early recanalization is a major prognostic factor in vascular accidents ischemic brain injury (AIC). The acute phase therapies of AIC aim to recanalization by intravenous thrombolysis and/or mechanical thrombectomy. Recanalization is identified immediately during thrombectomy by per-procedural arteriography. For the thrombolysis, only a performed MRI will validate the recanalization. This "proof of concept" study aims to identify an Electro-Encephalographic biomarker (EEG) of the recanalization in real time, the EEG being easy to set up. This biomarker will be sought during recanalization certified by thrombectomy in order to identify the window time for which the biomarker must be sought on the EEG. During this study, the identified EEG biomarker can be used to validate the recanalization during the intravenous thrombolysis in future studies

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-07-22
• Study First Submitted QC: 2022-07-22
• Study First Posted: 2022-07-26
• Study Start: 2023-01-24
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-13
• Last Update Posted: 2023-11-14
• Primary Completion: 2025-01-23
• Study Completion: 2025-07-23

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Patient over 18 years old
• Presenting a cerebral infarction with proximal occlusion of the sylvian artery requiring thrombectomy
• No objection to participation in the study

Exclusion Criteria

• Pregnant or breastfeeding women
• Patient benefiting from legal protection
• Absence of affiliation to a social protection scheme
• Recent cranial surgery not allowing the installation of a scalp EEG

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IElectro-Encephalographic (EEG) marker of recanalization	inclusion visit	dentification of an Electro-Encephalographic (EEG) marker of recanalization in patients with cerebral infarction with proximal occlusion of the sylvian artery and recanalized by mechanical thrombectomy

Trial Locations

Locations (1)

Fondation Ophtalmologique A. de Rothschild; 🇫🇷 Paris, France