Prevalence of Thyroid Dysfunction and Anti-thyroid Antibodies in Infertile Women
- Conditions
- Infertility, Female
- Interventions
- Diagnostic Test: Hormonal assayDiagnostic Test: Antibody assay
- Registration Number
- NCT03964779
- Lead Sponsor
- Cairo University
- Brief Summary
The study population will be divided into three groups:
* Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility,
* Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and
* Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group.
. All women will be subjected to:
* Informed consent
* Full history taking, including age, duration of infertility and whether primary or secondary
* General and pelvix examination
* Trans-vaginal ultrasonography
* Determination of hormonal profile (FSH, LH, Estradiol, Prolactin)
* Determination of ovulatory status
* Determination of of tubal patency
* Determination of presence of male factor
* Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels
- Detailed Description
The study population will be divided into three groups:
* Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility,
* Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and
* Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group.
. All women will be subjected to:
* Informed consent
* Full history taking, including age, duration of infertility and whether primary or secondary
* General and pelvix examination
* Trans-vaginal ultrasonography
* Determination of hormonal profile (FSH, LH, Estradiol, Prolactin)
* Determination of ovulatory status (by previous documented history of induction of ovulation OR previous ultrasonography OR previous estimation midluteal serum progesterone, etc ...)
* Determination of of tubal patency (by previous hysterosalpingiography or laparoscopy)
* Determination of presence of male factor (by seminal fluid analysis)
* Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 120
-
- Age: 18 - 38 years
- Infertile women whether due to functional, anatomical, male factors OR unexplained OR combined factors
-
- Age: below 18 and above 38 years
- Patients with autoimmune diseases (such as lupus and rheumatoid arthritis)
- Acute illness that require hospitalization
- Patients on the following medications: steroids, dopamine, iodine, amiodarone, lithium, donperidone, thyroid hormone, and phenytoin.
- Patients who work at night.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Tubal factor women Hormonal assay 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility male factor couple Antibody assay 40 women with exclusive male factor of infertility and will be used as a control group Anovulatory women Antibody assay 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility Tubal factor women Antibody assay 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility Anovulatory women Hormonal assay 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility male factor couple Hormonal assay 40 women with exclusive male factor of infertility and will be used as a control group
- Primary Outcome Measures
Name Time Method prevalence of thyroid dysfunction among infertile women through study completion, an average of 6 months prevalence of thyroid dysfunction (clinical or subclinical, hypothyroidism or hyperthyroidism) among infertile women
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kasr Alainy medical school
🇪🇬Cairo, Egypt