The role of the neurotransmitters dopamine and acetylcholine in the interaction of selective attention and working memory. - Dopamine and Acetylcholine for Attention and Memory
Phase 1
- Conditions
- Healthy volunteersMedDRA version: 12.0Level: LLTClassification code 10012271Term: Dementia Alzheimer's typeMedDRA version: 12.0Level: LLTClassification code 10013113Term: Disease Parkinson's
- Registration Number
- EUCTR2009-011093-15-DE
- Lead Sponsor
- Otto-von-Guericke University, Medical Faculty, Dpt. of Neurology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 0
Inclusion Criteria
Healthy subjects between 18-30 years (young group), healthy subjects between 60-80 years (old group)
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Pregnancy, nursing, glaucoma, severe heart, lung or liver disease, contraindications against MRI, psychiatric co-morbidity, unable to understand the study, intake of anticholinergic or antidopaminergic drugs
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Effects of IMPs on memory and attention performance (reaction times, accuracy);Secondary Objective: Age dependency of the above effects?;Primary end point(s): Memory and attention performance as assessed by neuropsychological tests after treatment with placebo vs. IMP 1 or placebo vs IMP 2, respectively.
- Secondary Outcome Measures
Name Time Method