Effects of a Chewing Gum Containing POs-Ca and Fluoride on Enamel

Early Phase 1

Completed

• Conditions: Enamel Subsurface Lesion
• Interventions: Dietary Supplement: chewing gum

• Registration Number: NCT01377493
• Lead Sponsor: Tokyo Medical and Dental University

Brief Summary

There were no differences in the degree of enamel remineralization of subsurface lesions among the chewing gums containing or not containing POs-Ca and fluoride.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-12
• Primary Completion: 2010-02
• Status Verified: 2011-06
• Study Completion: 2011-06
• Study First Submitted: 2011-06-17
• Study First Submitted QC: 2011-06-20
• Last Update Submitted: 2011-06-20
• Study First Posted: 2011-06-21
• Last Update Posted: 2011-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• healthy adult subjects
• More than 22 permanent teeth

Exclusion Criteria

• Alcohol addiction
• Smoking
• Active caries
• Periodontal pockets
• Low-saliva flow (less than 0.3ml/min)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
placebo	chewing gum	-
POs-Ca	chewing gum	-
POs-Ca+F	chewing gum	-

Primary Outcome Measures

Name	Time	Method
Mineral content of enamel	2 weeks	Mineral content of bovine enamel blocks inserted into the subject mouth during chewing of the gums was assessed.