Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease
- Registration Number
- NCT02914561
- Lead Sponsor
- Galapagos NV
- Brief Summary
The primary objectives of this study are to evaluate the safety and efficacy of filgotinib during induction and maintenance treatment of moderately to severely active Crohn's disease (CD) in participants who are biologic-naive and biologic-experienced.
Participants who complete the study, or do not meet protocol response or remission criteria at Week 10 will have the option to enter a separate long-term extension (LTE) study (Study GS-US-419-3896).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1372
- Documented diagnosis of CD with a minimum disease duration of 3 months with involvement of the ileum and/or colon at a minimum, as determined by histopathology and endoscopic assessment
- Moderately to severely active CD
- Cohort A (Biologic Naïve): Previously demonstrated an inadequate clinical response, loss of response to, or intolerance to at least 1 of the following agents (depending on current country treatment recommendations/guidelines): corticosteroids and immunomodulators
- Cohort A (Biologic Experienced): Previously demonstrated an inadequate clinical response, loss of response to, or intolerance to at least 1 of the following agents (depending on current country treatment recommendations/guidelines) or discontinuation of use of at least one of the following agents for reasons other than inadequate clinical response, loss of response or intolerance: tumor necrosis factor alpha (TNFa) antagonists, vedolizumab, and ustekinumab
- Cohort B (Biologic Experienced): Previously demonstrated an inadequate clinical response, loss of response to, or intolerance to at least 1 of the following agents (depending on current country treatment recommendations/guidelines): TNFa antagonists, vedolizumab, and ustekinumab
Key
- Current complications of CD such as symptomatic strictures, severe rectal/anal stenosis, fistulae other than perianal fistulae, short bowel syndrome, etc.
- Presence of ulcerative colitis, indeterminate colitis, ischemic colitis, fulminant colitis, or toxic mega-colon
- Active tuberculosis (TB) or history of latent TB that has not been treated
- Use of any prohibited concomitant medications as described in the study protocol
NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Filgotinib 200 mg to Filgotinib 200 mg (Maintenance Study) Filgotinib Participants who received filgotinib 200 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, up to Week 58. Filgotinib 100 mg to Filgotinib 100 mg (Maintenance Study) Filgotinib Participants who received filgotinib 100 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58. Cohort A: Filgotinib 100 mg (Induction Study) Filgotinib Biologic naïve and biologic experienced participants received filgotinib 100 mg with PTM filgotinib 200 mg tablet orally once daily, for a period of 10 weeks. Cohort A: Filgotinib 200 (mg) (Induction Study) Placebo Biologic naïve and biologic experienced participants received filgotinib 200 milligram (mg) with placebo-to-match (PTM) filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Cohort B: Placebo (Induction Study) Placebo Biologic experienced participants received PTM filgotinib 200 mg with PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Cohort A: Filgotinib 100 mg (Induction Study) Placebo Biologic naïve and biologic experienced participants received filgotinib 100 mg with PTM filgotinib 200 mg tablet orally once daily, for a period of 10 weeks. Cohort B: Filgotinib 200 mg (Induction Study) Placebo Biologic experienced participants received filgotinib 200 mg with PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Filgotinib 100 mg to Placebo (Maintenance Study) Placebo Participants who received filgotinib 100 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, up to Week 58. Cohort A: Filgotinib 200 (mg) (Induction Study) Filgotinib Biologic naïve and biologic experienced participants received filgotinib 200 milligram (mg) with placebo-to-match (PTM) filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Cohort B: Filgotinib 100 mg (Induction Study) Placebo Biologic experienced participants received filgotinib 100 mg with PTM filgotinib 200 mg tablet orally once daily, for a period of 10 weeks. Filgotinib 100 mg to Placebo (Maintenance Study) Filgotinib Participants who received filgotinib 100 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, up to Week 58. Filgotinib 200 mg to Placebo (Maintenance Study) Placebo Participants who received filgotinib 200 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58. Cohort A: Placebo (Induction Study) Placebo Biologic naïve and biologic experienced participants received PTM filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Cohort B: Placebo (Induction Study) Filgotinib Biologic experienced participants received PTM filgotinib 200 mg with PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Placebo to Placebo (Maintenance Study) Placebo Participants who received placebo in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58. Cohort A: Placebo (Induction Study) Filgotinib Biologic naïve and biologic experienced participants received PTM filgotinib 200 mg and PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Cohort B: Filgotinib 200 mg (Induction Study) Filgotinib Biologic experienced participants received filgotinib 200 mg with PTM filgotinib 100 mg tablet orally once daily, for a period of 10 weeks. Cohort B: Filgotinib 100 mg (Induction Study) Filgotinib Biologic experienced participants received filgotinib 100 mg with PTM filgotinib 200 mg tablet orally once daily, for a period of 10 weeks. Filgotinib 200 mg to Placebo (Maintenance Study) Filgotinib Participants who received filgotinib 200 mg in induction study and who achieved either clinical remission by PRO2 or endoscopic response at Week 10 were re-randomized to the maintenance study and received PTM filgotinib 100 mg and PTM filgotinib 200 mg tablet orally once daily, up to Week 58.
- Primary Outcome Measures
Name Time Method Induction Study: Percentage of Participants Who Achieved Clinical Remission by Crohn's Disease Activity Index (CDAI) at Week 10 Week 10 The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The subscores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.
Clinical remission was defined as a CDAI of \< 150 points.Induction Study: Percentage of Participants Who Achieved Endoscopic Response at Week 10 Week 10 The Simple Endoscopic Score for Crohn's Disease (SES-CD) assessed the degree of inflammation on the basis of 4 components: size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each of these components was scored on a scale of 0 to 3 (worst). In the SES-CD, each of these 4 components are assessed in the five segments: ileum, right colon, transverse colon, left colon, and rectum. The SES-CD was the sum of the individual scores of each of the components across the five segments. The range of SES-CD scores was 0 - 12 for each segment, and 0 - 60 for the overall SES-CD score, with larger scores indicating greater severity of disease. Endoscopic response was defined as ≥ 50% reduction from baseline in total SES-CD score.
Maintenance Study: Percentage of Participants Who Achieved Clinical Remission by CDAI at Week 58 Week 58 The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The sub scores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.
Clinical remission was defined as a CDAI of \< 150 points.Maintenance Study: Percentage of Participants Who Achieved Endoscopic Response at Week 58 Week 58 The SES-CD assessed the degree of inflammation on the basis of 4 components: size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each of these components was scored on a scale of 0 to 3 (worst). In the SES-CD, each of these 4 components are assessed in the five segments: ileum, right colon, transverse colon, left colon, and rectum. The SES-CD was the sum of the individual scores of each of the components across the five segments. The range of SES-CD scores was 0 - 12 for each segment, and 0 - 60 for the overall SES-CD score, with larger scores indicating greater severity of disease. Endoscopic response was defined as ≥ 50% reduction from baseline in total SES-CD score.
- Secondary Outcome Measures
Name Time Method Maintenance Study: Percentage of Participants Who Achieved Sustained Clinical Remission by PRO2 at Both Weeks 10 and 58 Weeks 10 and 58 The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days.
Sustained Clinical Remission by PRO2: liquid or very soft stool ≤3 and abdominal pain ≤1 combined at both Week 10 and Week 58.Induction Study: Percentage of Participants Who Achieved Clinical Remission by PRO2 at Week 10 Week 10 The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days. Clinical Remission was defined as the average daily stool score ≤3 points AND average daily abdominal pain score ≤1 point.
Induction Study: Percentage of Participants Who Achieved Clinical Response by CDAI at Week 10 Week 10 The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The subscores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.
Clinical response was defined as reduction in CDAI score from Induction baseline by at least 100 points or CDAI score \< 150 points.Maintenance Study: Percentage of Participants Who Achieved Clinical Remission by PRO2 at Week 58 Week 58 The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days. Clinical Remission was defined as the average daily stool score ≤3 points AND average daily abdominal pain score ≤1 point.
Maintenance Study: Percentage of Participants Who Achieved Clinical Response by CDAI at Week 58 Week 58 The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The sub scores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.
Clinical response was defined as reduction in CDAI score from Induction baseline by at least 100 points or CDAI score \< 150 points.Maintenance Study: Percentage of Participants Who Achieved Sustained Clinical Remission by CDAI at Both Weeks 10 and 58 Weeks 10 and 58 The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The sub scores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.
Sustained Clinical Remission by CDAI: CDAI \<150 combined at both Week 10 and Week 58.Maintenance Study: Percentage of Participants Who Achieved 6 Month Corticosteroid-Free Remission by CDAI at Week 58 Week 58 The CDAI system was a composite index of 8 disease activity variables: severity of abdominal pain, general well-being, very soft/liquid stool frequency, extra-intestinal symptoms, need for antidiarrheal drugs, presence of an abdominal mass, body weight and hematocrit. Participants reported information regarding symptoms using a diary. The subscores of abdominal pain (0-3), general well-being (0-4), and number of very soft or liquid stools were then summed over the 7 days prior to each visit. Additionally, the remaining predictors were also noted and weighted to create the total CDAI score which ranged from 0-600 with a higher score indicating a worse outcome.
6-Month Corticosteroid-Free Clinical remission by CDAI: CDAI \<150 with no corticosteroid use for indication of Crohn's disease for at least 6 months prior to Week 58.Maintenance Study: Percentage of Participants Who Achieved 6 Month Corticosteroid-Free Remission by PRO2 at Week 58 Week 58 The PRO2 was a composite score based on 2 components of the CDAI, the number of liquid or soft stools/day for 7 days, stool frequency and abdominal pain (rated on a scale of 0-3) assessed for 7 days.
6-month Corticosteroid-Free Clinical Remission by PRO2: liquid or very soft stool ≤3 and abdominal pain ≤1 with no corticosteroid use for at least 6 months prior to Week 58.Induction Study:Pharmacokinetic Plasma Concentrations of Filgotinib at Week 4 Week 4: 0.5, 1, 2, and 3 hours (hrs) post dose Plasma concentrations of filgotinib \[nanogram/milliliters (ng/mL)\].
Induction Study: Pharmacokinetic Plasma Concentrations of Filgotinib at Week 10 Week 10: Predose Plasma concentrations of filgotinib (ng/mL).
Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib at Week 26 Week 26: At any timepoint Plasma concentrations of filgotinib (ng/mL).
Induction Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 10 Week 10: Predose Plasma concentrations of GS-829845 (ng/mL).
Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib at Week 58 Week 58: Pre-dose Plasma concentrations of filgotinib (ng/mL).
Induction Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 4 Week 4: 0.5, 1, 2, and 3 hrs post dose Plasma concentrations of GS-829845 (ng/mL).
Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 26 Week 26: At any timepoint Plasma concentrations of GS-829845 (ng/mL).
Maintenance Study: Pharmacokinetic Plasma Concentrations of Filgotinib's Metabolite GS-829845 at Week 58 Week 58: Pre-dose Plasma concentrations of GS-829845 (ng/mL).
Trial Locations
- Locations (512)
Massachusetts General Hospital - Crohn's and Colitis Center
🇺🇸Boston, Massachusetts, United States
Kelsey-Seybold Clinic
🇺🇸Houston, Texas, United States
The University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States
Gulf Coast Research Group
🇺🇸Houston, Texas, United States
Advanced Pharma CR
🇺🇸Miami, Florida, United States
Vista Health Research, LLC
🇺🇸Miami, Florida, United States
UC Health Physicians Clifton
🇺🇸Cincinnati, Ohio, United States
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
Southern California Research Center, Inc.
🇺🇸Coronado, California, United States
Arizona Digestive Health - Sun City
🇺🇸Sun City, Arizona, United States
VVCRD Research
🇺🇸Garden Grove, California, United States
UC San Diego Health System
🇺🇸La Jolla, California, United States
Inland Empire Clinical Trials, LLC
🇺🇸Rialto, California, United States
Clearview Medical Research, LLC
🇺🇸Santa Clarita, California, United States
Connecticut GI, PC-Research Division
🇺🇸Farmington, Connecticut, United States
South Denver Gastroenterology, PC
🇺🇸Lone Tree, Colorado, United States
Medstar Georgetown University Hospital (Patient Exams)
🇺🇸Washington, District of Columbia, United States
Advanced Research, LLC
🇺🇸Coral Springs, Florida, United States
Florida Center for Gastroenterology
🇺🇸Largo, Florida, United States
Florida Research Institute
🇺🇸Lakewood Ranch, Florida, United States
Cordova Research Institute
🇺🇸Miami, Florida, United States
University of Miami Crohn's and Colitis Center
🇺🇸Miami, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
Gulf Region Clinical Research Institute
🇺🇸Pensacola, Florida, United States
Advanced Medical Research Center
🇺🇸Port Orange, Florida, United States
Shafran Gastroenterology Center
🇺🇸Winter Park, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
Gastroenterology Associates of Central Georgia, LLC
🇺🇸Macon, Georgia, United States
Atlanta Gastroenterology Specialist, PC
🇺🇸Suwanee, Georgia, United States
Gastrointestinal Specialists of Georgia
🇺🇸Marietta, Georgia, United States
Illinois Gastroenterology Group - Arlington Heights
🇺🇸Arlington Heights, Illinois, United States
Northwestern University, Feinberg School of Medicine
🇺🇸Chicago, Illinois, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
Illinois Gastroenterology Group - Gurnee
🇺🇸Gurnee, Illinois, United States
Indiana University Health University Hospital
🇺🇸Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
Louisiana Research Center, LLC
🇺🇸Shreveport, Louisiana, United States
Delta Research Partners, LLC
🇺🇸Monroe, Louisiana, United States
Investigative Clinical Research
🇺🇸Annapolis, Maryland, United States
University of Maryland Medical Center
🇺🇸Baltimore, Maryland, United States
Gastro Center of Maryland
🇺🇸Columbia, Maryland, United States
MGG Group Co., Inc., Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Meritus Center for Clinical Research
🇺🇸Hagerstown, Maryland, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Spectrum Health Butterworth Hospital
🇺🇸Grand Rapids, Michigan, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
NY Scientific
🇺🇸Brooklyn, New York, United States
New York University School of Medicine/NYU Gastroenterology Associates
🇺🇸New York, New York, United States
NYU Langone Long Island Clinical Research Associates
🇺🇸Great Neck, New York, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Premier Medical Group of the Hudson Valley
🇺🇸Poughkeepsie, New York, United States
Charlotte Gastroenterology & Hepatology, PLLC
🇺🇸Charlotte, North Carolina, United States
Carolina's GI Research, LLC
🇺🇸Raleigh, North Carolina, United States
Consultants for Clinical Research
🇺🇸Cincinnati, Ohio, United States
Paramount Medical Research & Consulting, LLC
🇺🇸Middleburg Heights, Ohio, United States
Great Lakes Gastroenterology Research, LLC,
🇺🇸Mentor, Ohio, United States
Great Lakes Medical Research, LLC
🇺🇸Harrisburg, Pennsylvania, United States
Gastroenterology Associates of Orangeburg
🇺🇸Orangeburg, South Carolina, United States
Options Health Research LLC
🇺🇸Tulsa, Oklahoma, United States
WR-ClinSearch, LLC
🇺🇸Chattanooga, Tennessee, United States
Texas Clinical Research Institute
🇺🇸Arlington, Texas, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
San Antonio Military Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Inquest Clinical Research
🇺🇸Baytown, Texas, United States
DHAT Research Institute
🇺🇸Garland, Texas, United States
Baylor College of Medicine- Baylor Medical Center
🇺🇸Houston, Texas, United States
The Methodist Hospital
🇺🇸Houston, Texas, United States
Centex Studies, Inc.
🇺🇸Houston, Texas, United States
Texas Digestive Disease Consultants (IP Shipment)
🇺🇸Southlake, Texas, United States
TDDC San Marcos
🇺🇸San Marcos, Texas, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Spring Gastroenterology
🇺🇸The Woodlands, Texas, United States
HP Clinical Research
🇺🇸Bountiful, Utah, United States
University of Virginia Health System
🇺🇸Charlottesville, Virginia, United States
Charlottesville Medical Research Center, LLC
🇺🇸Charlottesville, Virginia, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
University of Wisconsin Hospital & Clinics
🇺🇸Madison, Wisconsin, United States
Fundacion Estudios Clinicos CiRec
🇦🇷Rosario, Argentina
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
St. Vincent's Hospital Sydney
🇦🇺Darlinghurst, New South Wales, Australia
Monash Medical Centre
🇦🇺Clayton, New South Wales, Australia
Coastal Digestive Health
🇦🇺Mountain Creek, Queensland, Australia
Wollongong Hospital
🇦🇺Wollongong, New South Wales, Australia
Coral Sea Clinical Research Institute (Mackay)
🇦🇺North Mackay, Queensland, Australia
Mater Misericordiae Ltd
🇦🇺South Brisbane, Queensland, Australia
Flinders Medical Centre
🇦🇺Bedford Park, South Australia, Australia
The Queen Elizabeth Hospital
🇦🇺Woodville South, South Australia, Australia
Emeritus Research
🇦🇺Camberwell, Victoria, Australia
Footscray Hospital
🇦🇺Footscray, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Cabrini Hospital
🇦🇺Malvern, Victoria, Australia
Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
AKH-Medizinische Universitat Wien
🇦🇹Wien, Austria
Universitatsklinik Innsbruck
🇦🇹Innsbruck, Austria
GZA Ziekenhuizen campus Sint-Vincentius
🇧🇪Antwerpen, Belgium
CUB Hopital Erasme
🇧🇪Brussel, Belgium
Imelda General Hospital
🇧🇪Bonheiden, Belgium
Medical Center - Complete Medical Solutions OOD
🇧🇬Samokov, Bulgaria
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Universitair Ziekenhuis Leuven
🇧🇪Leuven, Belgium
CHR Citadelle
🇧🇪Liege, Belgium
AZ Delta Campus Wilgenstraat
🇧🇪Roeselare, Belgium
Centre Hospitalier Chretien (CHC) - Clinique Saint-Joseph
🇧🇪Liège, Belgium
"MDHAT Dr. St.Cherkezov" AD
🇧🇬Veliko Tarnovo, Bulgaria
Medical Center - "Tsaritsa Yoanna" EOOD
🇧🇬Sliven, Bulgaria
Barrie GI Associates
🇨🇦Barrie, Canada
MHAT "Sveta Petka" AD
🇧🇬Vidin, Bulgaria
University of Calgary, Heritage Medical Research Clinic
🇨🇦Calgary, Canada
London Health Sciences Centre - University Hospital
🇨🇦London, Canada
Hamilton Health Sciences Corporation, McMaster University Medical Centre
🇨🇦Hamilton, Canada
TIDHI Innovation Inc.
🇨🇦North York, Canada
ABP Research Services
🇨🇦Oakville, Canada
Royal University Hospital
🇨🇦Saskatoon, Canada
Toronto Digestive Disease Associates Inc.
🇨🇦Vaughan, Canada
The Gordon and Leslie Diamond Health Care Centre
🇨🇦Vancouver, Canada
Percuro Clinical Research Ltd.
🇨🇦Victoria, Canada
University Hospital Center Osijek
🇭🇷Osijek, Croatia
Clinical Hospital Dubrava
🇭🇷Zagreb, Croatia
University Hospital Center Zagreb
🇭🇷Zagreb, Croatia
Hepato-Gastroenterologie HK, s.r.o.
🇨🇿Hradec Kralove, Czechia
Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje, Gastroenterologicke oddeleni
🇨🇿Mlada Boleslav, Czechia
G.E.P. Clinic, s r.o.
🇨🇿Praha 3, Czechia
Thomayerova nemocnice, Interni klinika 3. LF UK a TN (Interni Oddeleni)
🇨🇿Praha 4, Czechia
CHU Amiens Picardie
🇫🇷Amiens Cedex 1, France
ISCARE a.s. (Klinicke centrum ISCARE), Klinicke a vyzkumne centrum pro strevni zanety
🇨🇿Praha 9, Czechia
CHU de Caen
🇫🇷Caen Cedex 9, France
CHU de Clermont-Ferrand - Hopital d'Estaing
🇫🇷Clermont-Ferrand, France
APHP - Hopital Beaujon - Clichy - Universite Paris VII
🇫🇷Clichy, France
Centre Hospitalier Intercommunal de Creteil
🇫🇷Créteil, France
CHU Grenoble Alpes
🇫🇷La Tronche, France
CHU de Dijon Bourgogne - Hopital Francois Mitterand
🇫🇷Dijon, France
Hopital Universitaire de Bicetre
🇫🇷Le Kremlin Bicetre, France
Hopital Nord
🇫🇷Marseille, France
Centre Hospitalier Regional Universitaire de Lille
🇫🇷Lille, France
CHU de Montpellier-Hopital Saint Eloi
🇫🇷Montpellier, France
CHU de Bordeaux - Hopital Haut Leveque
🇫🇷Pessac, France
Hopital de l'Archet 2
🇫🇷Nice, France
Centre Hospitalier Universitaire de Lyon Sud
🇫🇷Pierre-Benite, France
Centre d'Investigation Clinique - CHU Hotel-Dieu
🇫🇷Nantes, France
CH Annecy Genevois - Site d'Annecy
🇫🇷Pringy Cedex, France
CHU de Saint-Etienne - Hopital Nord
🇫🇷Saint Priest en Jarez, France
Nouvel Hopital Civil
🇫🇷Strasbourg, France
Hopitaux Universitaires de Strasbourg - Hopital de Hautepierre
🇫🇷Strasbourg, France
Unimed Ajara LLC - Batumi Referral Hospital
🇬🇪Batumi, Georgia
CHU de Toulouse - Hopital Rangueil
🇫🇷Toulouse, France
CHU de Nancy - Hopital Brabois Adultes
🇫🇷Vandoeuvre-les-Nancy Cedex, France
Medi Club Georgia LLC
🇬🇪Tbilisi, Georgia
Ltd. Unimed Kakheti - Telavi Referral Hospital
🇬🇪Telavi, Georgia
Charite Universitaetsmedizin Berlin
🇩🇪Berlin, Germany
Gastro-Studien
🇩🇪Berlin, Germany
DRK Kliniken Berlin - Westend - Klinik fuer Innere Medizin
🇩🇪Berlin, Germany
Charite - Universitatsmedizin Berlin
🇩🇪Berlin, Germany
Stadtisches Klinikum Braunschweig gGmbH
🇩🇪Braunschweig, Germany
Agaplesion Markus Krankenhaus
🇩🇪Frankfurt am Main, Germany
Universitatsklinikum Freiburg
🇩🇪Freiburg, Germany
Asklepios Westklinikum Hamburg
🇩🇪Hamburg, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitatsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Praxis fur Gastroenterologie
🇩🇪Heidelberg, Germany
Gastroenterologische Gemeinschaftspraxis Herne
🇩🇪Herne, Germany
Universitatsklinikum Jena
🇩🇪Jena, Germany
Universitatsklinikum Schleswig-Holstein
🇩🇪Kiel, Germany
EUGASTRO GmbH
🇩🇪Leipzig, Germany
Universitatsklinik Koln
🇩🇪Koln, Germany
Universitatsklinikum Leipzig
🇩🇪Leipzig, Germany
Gastroenterologische Gemeinschaftspraxis Minden
🇩🇪Minden, Germany
Klinikum Luneburg
🇩🇪Lüneburg, Germany
Klinikum der Universitat Munchen - Grosshadern
🇩🇪Muenchen, Germany
Universitaetsklinikum Tuebingen
🇩🇪Tuebingen, Germany
Universitaetsmedizin Rostock, Zentrum fuer Innere Medizin
🇩🇪Rostock, Germany
General Hospital of Athens "Hippokratio", 2nd Internal Medicine Clinic of Athens University, Hepato-gastroenterology Unit
🇬🇷Athens, Greece
Universitatsklinikum Ulm, Zentrum Fur Innere Medizin
🇩🇪Ulm, Germany
University General Hospital "Attikon", 2nd Propaedeutic Internal Medicine Dept. and Research Unit, Hepatogastroenterology Unit
🇬🇷Athens, Greece
University General Hospital of Ioannina, Gastroenterology Department, Internal Medicine Division
🇬🇷Ioannina, Greece
Princess Margaret Hospital
🇭🇰Hong Kong, Hong Kong
General Hospital of Thessaloniki "Hippokratio", 4th Internal Medicine Department of Aristotle University of Thessaloniki
🇬🇷Thessaloniki, Greece
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital
🇭🇰Shatin, Hong Kong
Tuen Mun Hospital
🇭🇰Tuen Mun, Hong Kong
Clinexpert Egeszsegugyi Szolgaltato es Kereskedelmi Kft.
🇭🇺Budapest, Hungary
Szent Margit Korhaz, Gasztroenterológiai Osztály
🇭🇺Budapest, Hungary
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, Kozponti Felnott Szakrendelo
🇭🇺Budapest, Hungary
Szent Janos Korhaz es Eszak-budai Egitett Korhazak, I. Belgyogyaszati - Gasztroenterologiai Osztaly
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont, II. sz. Belgyogyaszati Klinika, Gasztroenterologia
🇭🇺Debrecen, Hungary
Karolina Korhaz es Rendelointezet, Altalanos Belgyogyaszat-Gasztroenterologia
🇭🇺Mosonmagyarovar, Hungary
Landspitali University Hospital
🇮🇸Reykjavik, Iceland
Kaizen Hospital
🇮🇳Ahmedabad, India
Sal Hospital and Medical Institute
🇮🇳Ahmedabad, India
Victoria Hospital, Bangalore Medical College and Research Institute
🇮🇳Bangalore, India
M S Ramaiah Medical College and Hospital
🇮🇳Bangalore, India
KLES Dr. Prabhakar Kore Hospital & MRC
🇮🇳Belgaum, India
BGS Global Hospital
🇮🇳Bengaluru, India
Apollo Speciality Hospital
🇮🇳Chennai, India
VGM Hospital Institute of Gastroenterology
🇮🇳Coimbatore, India
Maharaja Agrasen Hospital
🇮🇳Delhi, India
Institute of Digestive & Liver Diseases
🇮🇳Guwahati, India
Aware Gleneagles Global Hospitals
🇮🇳Hyderabad, India
Citizens Specialty Hospital
🇮🇳Hyderabad, India
Centre for Liver Research & Diagnostics
🇮🇳Hyderabad, India
S.R.Kalla Memorial Gastro.&General Hospital
🇮🇳Jaipur, India
S.M.S Medical College & Hospitals
🇮🇳Jaipur, India
GSVM Medical College
🇮🇳Kanpur, India
Lakeshore Hospital and Research Centre Ltd.
🇮🇳Kochi, India
Amrita Institute of Medical Sciences and Research Centre
🇮🇳Kochi, India
Apollo Gleneagles Hospitals
🇮🇳Kolkata, India
School of Digestive & Liver Diseases
🇮🇳Kolkata, India
King George's Medical University
🇮🇳Lucknow, India
Dayanand Medical College & Hospital
🇮🇳Ludhiana, India
Midas Multispeciality Hospital Pvt. Ltd
🇮🇳Nagpur, India
Seth G.S Medical College & KEM Hospital
🇮🇳Mumbai, India
Lokmanya Tilak Municipal General Hospital
🇮🇳Mumbai, India
Kasturba Medical College (KMC) Hospital
🇮🇳Mangaluru, India
Dr. B.L. Kapur Memorial Hospital
🇮🇳New Delhi, India
Max Smart Super Speciality Hospital
🇮🇳New Delhi, India
All India Institute of Medical Sciences
🇮🇳New Delhi, India
Department of Surgery, B.J. Government Medical College & Sassoon General Hospital
🇮🇳Pune, India
Fortis Flt. Lt. Rajan Dhall Hospital
🇮🇳New Delhi, India
S.L Raheja Hospital
🇮🇳Parel, India
Grant Medical Foundation Ruby Hall Clinic
🇮🇳Pune, India
Gandhi Hospital
🇮🇳Secunderabad, India
Universal Hospital
🇮🇳Pune, India
Surat Institute of Digestive Sciences
🇮🇳Surat, India
BAPS Pramukh Swami Hospital
🇮🇳Surat, India
Shree Giriraj Multispeciality Hospital
🇮🇳Rajkot, India
Institute of Gastroenterology & Liver Disease. Sunshine Hospitals
🇮🇳Secunderabad, India
Beaumont Hospital
🇮🇪Dublin, Ireland
Wellcome Trust HRB Clinical Research Facility
🇮🇪Dublin, Ireland
Emek Medical Center
🇮🇱Afula, Israel
Soroka Medical Center
🇮🇱Be'er Sheva, Israel
The Edith Wolfson Medical Center
🇮🇱Holon, Israel
Rambam Health Care Campus
🇮🇱Haifa, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Israel
Meir Medical Center
🇮🇱Kefar Sava, Israel
Rabin Medical Center
🇮🇱Petah Tikva, Israel
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
UOC Gastroenterologia II
🇮🇹Castellana Grotte, Italy
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv-Yafo, Israel
Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
UOC Medicina Interna
🇮🇹Cento, Italy
U.O. Fisiopatologia Digestiva
🇮🇹Catanzaro, Italy
Gastroenterologia clinica - Azienda Ospedaliero-Universitaria Careggi
🇮🇹Firenze, Italy
Endoscopia Digestiva Centralizzata
🇮🇹Milano, Italy
Ospedale Clinicizzato SS. Annunziata - Dipartimento di Medicina
🇮🇹Chieti, Italy
UO Gastroenterologia
🇮🇹Modena, Italy
UOC Gastroenterologia
🇮🇹Padova, Italy
A.O. Ordine Mauriziano di Torino
🇮🇹Torino, Italy
UOC di Gastroenterologia ed Endoscopia Digestiva
🇮🇹Roma, Italy
Ohmori Toshihide gastro-intestinal Clinic
🇯🇵Ageo-shi, Japan
Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital
🇯🇵Chuo-ku, Japan
Japanese Red Cross Fukuoka Hospital
🇯🇵Fukuoka-shi, Japan
Tokyo Medical and Dental University Hospital
🇯🇵Bunkyo-ku, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Ofuna Chuo Hospital
🇯🇵Kamakura, Japan
Tsujinaka Hospital
🇯🇵Kashiwa-city, Japan
Saitama Medical Center, Saitama Medical University
🇯🇵Kawagoe, Japan
Kitakyushu City Hospital Organization Kitakyushu Municipal Medical Center
🇯🇵Kitakyushu-shi, Japan
Kurume University Hospital
🇯🇵Kurume-shi, Japan
University Hospital, Kyoto Prefectural University of Medicine
🇯🇵Kyoto-shi, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu-shi, Japan
Iwate Medical University Hospital
🇯🇵Morioka-shi, Japan
Nagasaki University Hospital
🇯🇵Nagasaki-shi, Japan
Saiseikai Niigata Daini Hospital
🇯🇵Nishi-ku, Japan
Ishida IBD Clinic
🇯🇵Oita-shi, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu, Japan
Wakakusa-Daiichi Hospital
🇯🇵Osaka, Japan
Tokito Clinic
🇯🇵Saitama, Japan
Osaka University Hospital
🇯🇵Suita, Japan
National Hospital Organization Takasaki General Medical Center
🇯🇵Takasaki-shi, Japan
Osaka Medical College Hospital
🇯🇵Takatsuki, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama-shi, Japan
Yokohama Health Medicine Association Kannai Suzuki Clinic
🇯🇵Yokohama-shi, Japan
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Guri-Si, Korea, Republic of
Hanyang University Guri Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam-si, Korea, Republic of
Yonsei University Health System, Severance Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Division of Gastroenterology, Department of Medicine, Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon-si, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju, Korea, Republic of
Hospital Queen Elizabeth
🇲🇾Kota Kinabalu, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
NZW Alkmaar (Noordwest Ziekenhuisgroep)
🇳🇱Alkmaar, Netherlands
Academic Medical Center (AMC)
🇳🇱Amsterdam, Netherlands
Gelre Hospital
🇳🇱Apeldoorn, Netherlands
Maastricht University Medical Centre
🇳🇱Maastricht, Netherlands
Erasmus University Medical Center
🇳🇱Rotterdam, Netherlands
Elisabeth-TweeSteden Hospital
🇳🇱Tilburg, Netherlands
Christchurch Hospital
🇳🇿Christchurch, New Zealand
Southern District Health Board - Dunedin Hospital
🇳🇿Dunedin, New Zealand
Auckland City Hospital
🇳🇿Grafton, New Zealand
Waikato Hospital
🇳🇿Hamilton, New Zealand
Wellington Hospital
🇳🇿Newtown, New Zealand
Bay of Plenty District Health Board - Tauranga Hospital
🇳🇿Tauranga, New Zealand
Hutt Valley District Health Board - Hutt Valley Hospital
🇳🇿Wellington, New Zealand
Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Gastroenterologii i Chorob Wewnetrznych
🇵🇱Bialystok, Poland
Vestre Viken Hospital Trust, Baerum Hospital
🇳🇴Drammen, Norway
VITAMED Galaj i Cichomski spolka jawna
🇵🇱Bydgoszcz, Poland
Szpital Uniwersytecki nr 2 im. Dr. Jana Biziela w Bydgoszczy, Centrum Endoskopii Zabiegowej, Poradnia Chorob Jelitowych
🇵🇱Bydgoszcz, Poland
NZOZ INTER-MED, Centrum Endoskopowe
🇵🇱Czestochowa, Poland
Gabinet Lekarski Janusz Rudzinski
🇵🇱Bydgoszcz, Poland
Niepubliczny Zaklad Opieki Zdrowotnej ALL-MEDICUS
🇵🇱Katowice, Poland
Gabinet Endoskopii Przewodu Pokarmowego
🇵🇱Krakow, Poland
Centrum Medyczno-Diagnostyczne Prima-Med
🇵🇱Kraków, Poland
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwerstyeckiego Szpitala Klinicznego nr 1 im. Norbert Barlickiego
🇵🇱Lodz, Poland
Gabinet Lekarski Dr. Hab. N. Med. Bartosz Korczowski
🇵🇱Rzeszów, Poland
Endoskopia Sp. Z o.o.
🇵🇱Sopot, Poland
Centro Hospitalar de Sao Joao, EPE
🇵🇹Porto, Portugal
H-T.Centrum Medyczne Spolka z Ograniczona Odpowiedzialnoscia Sp.K.
🇵🇱Tychy, Poland
Pinnacle Clinical Research
🇺🇸San Antonio, Texas, United States
Clinical Associates in Research Therapeutics of America, LLC
🇺🇸San Antonio, Texas, United States
Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie
🇵🇱Warsaw, Poland
Gastroenterology Research of San Antonio
🇺🇸San Antonio, Texas, United States
Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administacji w Warszawie
🇵🇱Warszawa, Poland
Centrum Zdrowia MDM
🇵🇱Warszawa, Poland
Niepubliczny Zaklad Opieki Zrodotnej VIVAMED Jadwige Miecz
🇵🇱Warszawa, Poland
Medical Concierge Centrum Medyczne
🇵🇱Warszawa, Poland
Centro Hospitalar e Universitario de Coimbra, E.P.E.
🇵🇹Coimbra, Portugal
SC MedLife SA, Gastroenterologie
🇷🇴Bucuresti, Romania
Centro Hospitalar Cova de Beira, EPE
🇵🇹Covilhã, Portugal
Centro Hospitalar do Algarve EPE
🇵🇹Faro, Portugal
Hospital Beatriz Angelo
🇵🇹Loures, Portugal
Delta Health Care/ Ponderas Academic Hospital
🇷🇴Bucuresti, Romania
Gastromedica SRL, Gastroenterologie
🇷🇴Iasi, Romania
State Budgetary Healthcare Institute "Chelyabinsk Regional Clinical Hospital"
🇷🇺Chelyabinsk, Russian Federation
Saint Petersburg State Budgetary Healthcare Institution "City Polyclinic #38"
🇷🇺Saint-Petersburg, Russian Federation
"Scientific Research Centre ECO-safety" LLC
🇷🇺Saint-Petersburg, Russian Federation
"PolyClinic EXPERT" LLC
🇷🇺Saint-Petersburg, Russian Federation
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Zvezdara University Medical Center
🇷🇸Belgrade, Serbia
Clinical Center of Vojvodina
🇷🇸Novi Sad, Serbia
National University Hospital
🇸🇬Singapore, Singapore
Singapore General Hospital
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Dr John P Wright
🇿🇦Cape Town, South Africa
Dr MJ Prins
🇿🇦Cape Town, South Africa
Peermed Clinical Trial Centre
🇿🇦Johannesburg, South Africa
Hospital Universitari Germans Trias i Pujol
🇪🇸Badalona, Spain
Centro Medico Teknon
🇪🇸Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Complejo Hospitalario Universitario de Ferrol
🇪🇸Ferrol, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
Hospital Universitario de Gran Canaria "Dr. Negrin"
🇪🇸Las Palmas de Gran Canaria, Spain
Hospital Universitario de Fuenlabrada
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Spain
Complejo Hospitalario Universitario de Pontevedra
🇪🇸Pontevedra, Spain
Hospital de Sagunto
🇪🇸Sagunto, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital de Galdakao-Usandolo
🇪🇸Usansolo, Spain
National Hospital of Sri Lanka
🇱🇰Colombo, Sri Lanka
Colombo North Teaching Hospital
🇱🇰Ragama, Sri Lanka
Danderyds Sjukhus AB
🇸🇪Danderyd, Sweden
Akademiska Sjukhuset
🇸🇪Uppsala, Sweden
Gastroenterologische Praxis Balsiger, Seibold und Partner
🇨🇭Bern, Switzerland
Universitatsspital Zurich
🇨🇭Zurich, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Changhua Christian Hospital
🇨🇳Changhua, Taiwan
Chang Shan Medical University Hospital
🇨🇳Taichung, Taiwan
Far Eastern Memorial Hospital
🇨🇳New Taipei City, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Bukovinian State Medical University
🇺🇦Chernivtsi, Ukraine
Municipal City Clinical Hospital of the Emergency Medical Care, 1 st Therapy Department. Danylo Halytsky Lviv National Medical
🇺🇦Chernivtsi, Ukraine
Chang Gung Medical Foundation, Chang Gung Memorial Hospital, Linkou Branch
🇨🇳Taoyuan, Taiwan
Municipal Health Care Institution "Kharkiv City Clinical Hospital #2 named after prof. O. O. Shalimov", Proctology Department
🇺🇦Kharkiv, Ukraine
Municipal Institution of Health Care "Regional Hospital of War Veterans", Therapeutic Department No1
🇺🇦Kharkiv, Ukraine
Treatment and Diagnostic Center of Private Enterprise of Private Production Company "Acinus"
🇺🇦Kropyvnytskyi, Ukraine
Municipal Non-profit Enterprise "Consultative and Diagnostic Center" of Pechersk District of Kyiv, Therapy Department
🇺🇦Kyiv, Ukraine
Municipal Institution "Odesa Regional Clinical Hospital", Regional Gastroenterology Center based on Surgery Department
🇺🇦Odessa, Ukraine
Ternopil University Hospital, Regional Center of Gastroenterology with Hepatology
🇺🇦Ternopil, Ukraine
Municipal Institution "Uzhgorod District Hospital", Therapy Department
🇺🇦Uzhgorod, Ukraine
Vinnytsia Regional Clinical Hospital of War Veterans, Therapy Department #1
🇺🇦Vinnytsia, Ukraine
Norfolk and Norwich University Hospital NHS Foundation Trust
🇬🇧Norwich, Norfolk, United Kingdom
Queen Elizabeth Hospital
🇬🇧Birmingham, United Kingdom
The Pennine Acute Hospitals NHS Trust
🇬🇧Bury, United Kingdom
Cambridge University Hospital NHS Foundation Trust
🇬🇧Cambridge, United Kingdom
Royal Derby Hospital
🇬🇧Derby, United Kingdom
Medical Outpatient Department
🇬🇧Exeter, United Kingdom
Glasgow Clinical Research Facility - Queen Elizabeth University Hospital
🇬🇧Glasgow, United Kingdom
NHS Greater Glasgow and Clyde
🇬🇧Glasgow, United Kingdom
Wycombe Hospital
🇬🇧High Wycombe, United Kingdom
Imperial College Healthcare NHS Trust, St Mary's Hospital
🇬🇧London, United Kingdom
Hull Royal Infirmary
🇬🇧Hull, United Kingdom
Oxford University Hospitals NHS Foundation Trust
🇬🇧Oxford, United Kingdom
St Helens and Knowsley Teaching Hospitals NHS Trust
🇬🇧Prescot, United Kingdom
Southampton National Institute for Health Research, Wellcome Trust Clinical Research Facility
🇬🇧Southampton, United Kingdom
Fargo Gastroenterology and Hepatology Clinic
🇺🇸Fargo, North Dakota, United States
S.P. Medical College & AG of Hospitals
🇮🇳Bīkaner, Rajasthan, India
Saga-Ken Medical Centre Koseikan
🇯🇵Saga-shi, Japan
Medical Center LLC "Health Clinic"
🇺🇦Vinnytsia, Ukraine
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Gleneagles Global Hospitals
🇮🇳Hyderabad, India
Hyogo College of Medicine College Hospital
🇯🇵Nishinomiya, Japan
AGA Clinical Research Associates, LLC
🇺🇸Egg Harbor Township, New Jersey, United States
Cedars Sinai Medical Center
🇺🇸Los Angeles, California, United States
Bugat Pal Korhaz, Belgyogyaszat
🇭🇺Gyöngyös, Hungary
Asian Institute of Gastroenterology Pvt Ltd
🇮🇳Hyderabad, India
Suretech Hospital & Research Centre Ltd
🇮🇳Nagpur, India
Kasturba Hospital Medical College
🇮🇳Udupi, India
St. Vincent's University Hospital
🇮🇪Dublin, Ireland
The Jikei University Hospital
🇯🇵Minato-ku, Japan
Aichi Medical University Hospital
🇯🇵Nagakute-shi, Japan
Kitasato University Hospital, THE KITASATO INSTITUTE
🇯🇵Sagamihara, Japan
Hospital Tengku Ampuan Afzan
🇲🇾Kuantan, Malaysia
Spitalul Universitar de Urgenta Militar Central Dr. Carol Davila - Sectia Clinica de Gastroenterologie
🇷🇴Bucuresti, Romania
Lourdes Hospital
🇮🇳Ernakulam, India
PVS Memorial Hospital Private Limited
🇮🇳Ernakulam, India
University Hospital Galway
🇮🇪Galway, Ireland
Hiroshima Prefectural Hospital
🇯🇵Hiroshima-shi, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo-shi, Japan
Universiti Kebangsaan Malaysia Medical Center
🇲🇾Cheras, Malaysia
Bodyclinic
🇵🇱Warszawa, Poland
Centrum Medyczne
🇵🇱Wroclaw, Poland
S.C. Centrul Medical Sana S.R.L., Gastroenterologie
🇷🇴Bucharest, Romania
Gastroplus Digestive Disease Centre Pvt Ltd
🇮🇳Ahmedabad, India
Fortis Medical Research Institute
🇮🇳Gurgaon, India
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Medical corporation Ryowakai, Hamamatsu South Hospital
🇯🇵Hamamatsu-shi, Japan
Fukuoka University Hospital
🇯🇵Jonan-ku, Japan
Sapporo Tokushukai Hospital
🇯🇵Sapporo, Japan
Ieda Hospital
🇯🇵Toyota-shi, Japan
University Medical Center Groningen (UMCG)
🇳🇱Groningen, Netherlands
Twoja Przychodnia-Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
GASTROMED Kopon, Zmudzkinski i Wspolnicy Sp. j. Specjalistyczne Centrum Gastrologii i Endoskopii
🇵🇱Torun, Poland
Hospital de Braga
🇵🇹Braga, Portugal
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
University General Hospital of Patras "Panagia I Voithia", Gastroenterology Department, Internal Medicine Division
🇬🇷Patras, Greece
Bekes Megyei Kosponti Korhaz, Dr. Rethy Pal Tagkorhaz, IV. Belgyogyaszat - 2. Gasztroenterologia
🇭🇺Bekescsaba, Hungary
Sterling Hospital
🇮🇳Vadodara, India
Samvedna Hospital
🇮🇳Varanasi, India
Tokai University Hachioji Hospital
🇯🇵Hachioji, Japan
Hidaka Coloproctology Clinic
🇯🇵Kurume-shi, Japan
Nagoya City University Hospital
🇯🇵Nagoya, Japan
Okayama University Hospital
🇯🇵Okayama-city, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka-City, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
National Hospital Organization Sendai Medical Center
🇯🇵Sendai, Japan
University Hospital Medical Center Bezanijska kosa
🇷🇸Belgrade, Serbia
Kyorin University Hospital
🇯🇵Mitaka-shi, Japan
Saga University Hospital
🇯🇵Saga, Japan
Krakowskie Centrum Medyczne Sp. z o.o.
🇵🇱Kraków, Poland
Trialmed Crs
🇵🇱Piotrków Trybunalski, Poland
WIP Warsaw IBD Point Profesor Kierkus
🇵🇱Warszawa, Poland
Unidade Local de Saude do Alto Minho, EPE
🇵🇹Viana do Castelo, Portugal
MedLife, Gastroenterologie
🇷🇴Bucuresti, Romania
State Budgetary Institution of Health Irkustsk Order "Badge of Honor" Regional Clinical Hospital
🇷🇺Irkutsk, Russian Federation
State Budgetary Healthcare Institution of the Novosibirsk Region "State Novosibirsk Regional Clinical Hospital"
🇷🇺Novosibirsk, Russian Federation
Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu-shi, Japan
Hospital Pulau Pinang
🇲🇾George Town, Malaysia
VU University Medical Centre
🇳🇱Amsterdam, Netherlands
Clinical Research Center Spolka z ograniczna odpowiedzialnoscia Medic-R Sp. k.
🇵🇱Poznan, Poland
Cabinet Particular Policlinic Algomed SRL
🇷🇴Timisoara, Romania
Centrul Medical Tuculanu, Gastroenterologie
🇷🇴Timisoara, Romania
S.C. Policlinica Dr. Citu S.R.L.- Gastroenterologie
🇷🇴Timisoara, Romania
State Budgetary Institution of Health of Novosibirsk Region "City Clinical Hospital #12"
🇷🇺Novosibirsk, Russian Federation
State Healthcare Institution "Regional Clinical Hospital"
🇷🇺Saratov, Russian Federation
Changi General Hospital
🇸🇬Singapore, Singapore
Cliniq s. r. o., Gastroenterologicke centrum Ruzinov
🇸🇰Bratislava, Slovakia
KM Management, s.r.o., Gastroenterologicke a hepatologicke centrum Nitra
🇸🇰Nitra, Slovakia
Gastro I., s.r.o.
🇸🇰Presov, Slovakia
State Institution "Institute of Gastroenterology of National Academy of Medical Sciences of Ukraine"
🇺🇦Dnipropetrovsk, Ukraine
M.I. Pyrogov Vinnytsia Regional Clinical Hospital, Gastroenterology Department
🇺🇦Vinnytsia, Ukraine
Hospital da Senhora da Oliveira Guimaraes, E.P.E.
🇵🇹Guimaraes, Portugal
Spitalul Universitar de Urgenta Bucuresti - Sectia Medicina Interna II
🇷🇴Bucharest, Romania
Clinical Hospital Center Zemun
🇷🇸Belgrade, Serbia
Municipal Institution "Zaporizhzhya Regional Clinical Hospital" of Zaporizhzhya Regional Council
🇺🇦Zaporizhzhya, Ukraine
Spitalul Clinic Colentina, Gastroenterologie
🇷🇴Bucuresti, Romania
Ivanto-Frankivsk Central City Clinic Hospital, Therapy Department #1. State Higher Education Institution Ivano-Frankivsk National
🇺🇦Ivano-Frankivsk, Ukraine
Kyiv City Clinical Hospital No. 18, Proctology Department
🇺🇦Kyiv, Ukraine
State Budgetary Healthcare Institution of Moscow "City Clinical Hospital # 24 of Healthcare Department of Moscow"
🇷🇺Moscow, Russian Federation
Mackay Memorial Hospital, Taipei
🇨🇳Taipei, Taiwan
State Budgetary Healthcare Institution of Moscow Region "Moscow Regional Clinical Research Institute n.a. M.F. Vladimirskiy"
🇷🇺Moscow, Russian Federation
State Budgetary Healthcare Institution of Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Hospital n.a. N.A.
🇷🇺Nizhniy Novgorod, Russian Federation
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
Kaiser Permanente
🇺🇸San Francisco, California, United States
Vanderbilt University Medical Center - IBD Clinic
🇺🇸Nashville, Tennessee, United States
Quality Medical Research
🇺🇸Nashville, Tennessee, United States
Nanpuh Hospital
🇯🇵Kagoshima-shi, Japan
Teaching hospital Karapitiya
🇱🇰Galle, Sri Lanka
Kandy Teaching Hospital
🇱🇰Kandy, Sri Lanka
Azienda Ospedaliero-Universitaria Pisana - Presidio Ospedaliero Cisanello
🇮🇹Pisa, Italy
NHS Lothian
🇬🇧Edinburgh, United Kingdom
Hopital Saint Joseph
🇫🇷Marseille, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
🇫🇷Rennes Cedex 9, France
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Wisconsin Center for Advanced Research, a division of GI Associates, LLC
🇺🇸Milwaukee, Wisconsin, United States
CED Studien UG, Interdisciplinary Crohn Colitis Center (iCCC) Rhein-Main
🇩🇪Frankfurt am Main, Germany
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Emeritas Research Group LLC
🇺🇸Leesburg, Virginia, United States
UF Clinical Research Center
🇺🇸Gainesville, Florida, United States
Center for Interventional Endoscopy - AdventHealth Orlando
🇺🇸Orlando, Florida, United States
University of Louisville, School of Medicine
🇺🇸Louisville, Kentucky, United States
Kansas City Research Institute
🇺🇸Kansas City, Missouri, United States
University of Colorado Denver and Hospital
🇺🇸Aurora, Colorado, United States
Tampa General Hospital
🇺🇸Tampa, Florida, United States
McGuire DVAMC, GI (111N)
🇺🇸Richmond, Virginia, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
University Medical Center Utrecht
🇳🇱Utrecht, Netherlands