NCT07314203尚未招募3 期
Clinical Efficacy of Adebrelimab With or Without Apatinib Mesilate and SOX Neoadjuvant Therapy in Locally Advanced Gastric Cancer
Fujian Medical University1 个研究点 分布在 1 个国家目标入组 118 人开始时间: 2026年12月25日最近更新:
适应症
干预措施
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 118
- 试验地点
- 1
- 主要终点
- Objective response rate
研究概览
简要总结
Exploring the pathological complete response rate (pCR) of locally advanced gastric cancer treated with adebelimab combined or not combined with apatinib mesylate and SOX neoadjuvant therapy
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •**Inclusion Criteria**
- •Age 18-75 years (inclusive).
- •Histologically or cytologically confirmed unresectable, locally advanced or metastatic HER2-negative adenocarcinoma of the stomach or gastro-oesophageal junction (GEJ).
- •3. No prior systemic chemotherapy, radiotherapy, targeted therapy, or immunotherapy for advanced disease. Subjects who have received prior (neo)adjuvant chemotherapy and/or radiotherapy are eligible provided the last dose was completed ≥ 6 months before randomisation.
- •4. At least one measurable lesion per RECIST 1.1 (see Appendix 2).
- •Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 (see Appendix 4).
- •6. Estimated life expectancy > 3 months.
- •Adequate major organ function defined as:
- •Haematology (obtained ≤ 14 days without transfusion):
- •Hb ≥ 80 g/L
- •WBC ≥ 3 × 10⁹/L
- •ANC ≥ 1.5 × 10⁹/L
- •PLT ≥ 100 × 10⁹/L
- •Biochemistry:
- •Total bilirubin < 1.5 × upper limit of normal (ULN)
- •ALT and AST < 2.5 × ULN; ALP ≤ 1.5 × ULN
- •Serum creatinine ≤ 1 × ULN and calculated creatinine clearance ≥ 60 mL/min (Cockcroft-Gault formula)
- •Women of child-bearing potential must have a negative serum pregnancy test within 7 days prior to enrolment and must use highly effective contraception from screening until 8 weeks after the last dose of study drug. Men must be surgically sterile or agree to use effective contraception during the same period.
- •9. No participation in any other interventional clinical trial during the pre-treatment or on-treatment phases of this study.
- •10. Voluntary written informed consent obtained; willing and able to comply with study procedures and follow-up.
排除标准
- •Exclusion Criteria
- •Subjects meeting any of the following conditions will be excluded from enrollment:
- •Known or suspected hypersensitivity to the investigational drug or any drug of the same class.
- •Other malignancies within the past 5 years, except adequately treated basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix.
- •Currently receiving treatment in another interventional clinical trial, or any systemic anti-gastric-cancer therapy within 4 weeks prior to the first dose.
- •Systemic Chinese patent medicines with anti-tumor indications or immunomodulatory agents (e.g., thymosin, interferon, interleukins; local intrapleural use for effusion control is permitted) received within 2 weeks before the first dose.
- •Prior exposure to: anti-PD-1, anti-PD-L1, anti-PD-L2, or any agent targeting other T-cell co-stimulatory or co-inhibitory pathways (including but not limited to CTLA-4, OX-40, CD137); or prior chemotherapy including S-
- •Live-vaccine administration within 4 weeks before enrollment or planned during the study.
- •Note: Inactivated seasonal influenza vaccine by injection is allowed within 4 weeks; intranasal live-attenuated influenza vaccine is prohibited.
- •Active autoimmune disease requiring systemic therapy (e.g., immunosuppressants, corticosteroids, or disease-modifying agents) within 2 years before the first dose. Replacement therapy (thyroxine, insulin, physiologic glucocorticoids for adrenal or pituitary insufficiency) is not considered systemic therapy.
- •Prior allogeneic bone-marrow or solid-organ transplantation.
- •Any condition that could impair drug absorption or inability to swallow oral medication.
- •Uncontrolled hypertension despite optimal medical management:
- •SBP ≥ 150 mmHg or DBP ≥ 100 mmHg on a single antihypertensive, or requirement of ≥ 2 antihypertensive agents.
- •Urinalysis showing proteinuria ≥ 2+ and 24-h urinary protein > 1.0 g.
- •Active gastro-duodenal ulcer, ulcerative colitis, or other gastrointestinal disorders with bleeding risk; un-resected tumors with active hemorrhage; or any other condition judged by the investigator to predispose to GI bleeding or perforation.
- •Significant bleeding tendency within 3 months before enrollment: overt bleeding > 30 mL, hematemesis, melena, hematochezia; hemoptysis (> 5 mL fresh blood within 4 weeks); or thrombo-embolic event (including stroke/TIA) within 12 months.
- •Clinically significant cardiovascular disease:
- •Acute MI, unstable/severe angina, or CABG within 6 months before enrollment;
- •NYHA class > II congestive heart failure;
- •Ventricular arrhythmia requiring therapy;
- •QTc ≥ 480 ms on baseline ECG.
- •Active or uncontrolled severe infection (≥ CTCAE grade 2).
- •Known HIV infection; clinically significant hepatic disorders:
- •Chronic hepatitis B with active replication (HBV DNA > 1 × 10⁴ copies/mL or > 2000 IU/mL);
- •Hepatitis C with detectable HCV RNA (> 1 × 10³ copies/mL);
- •Other hepatitis or cirrhosis.
- •Known dihydropyrimidine dehydrogenase (DPD) deficiency.
- •Any condition that, in the opinion of the investigator, would compromise the subject's safety or interfere with study participation.
研究组 & 干预措施
research group
Experimental
Study population received the combination of Adabelimab, Apatinib Mesylate, and SOX regimen
干预措施: Apatinib Mesylate Tablets (Drug)
结局指标
主要结局
Objective response rate
时间窗: 1 day
Objective Response Rate (ORR) is defined as the proportion of patients with confirmed complete response (CR) or partial response (PR) based on standardized, objective criteria (e.g., RECIST 1.1).
次要结局
- Median Overall Survival(according to the OS)
- Progression-Free Survival(36 months)
- Duration of Response(1 day)
- Adverse Event(30 days)
研究者
Chang-Ming Huang, Prof.
Chief doctor, phD, FACS
Fujian Medical University
研究点 (1)
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