Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

• Conditions: Thyroid Cancer; Breast Cancer

• Registration Number: NCT01811199
• Lead Sponsor: Marmara University

Brief Summary

Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.

Detailed Description

This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.

Study Timeline

• Study Start: 2011-02
• Status Verified: 2013-03
• Study First Submitted: 2013-03-06
• Study First Submitted QC: 2013-03-12
• Last Update Submitted: 2013-03-12
• Study First Posted: 2013-03-14
• Last Update Posted: 2013-03-14
• Primary Completion: 2013-04
• Study Completion: 2013-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent

Exclusion Criteria

• ones who did not sign the consent form NSAID or steroid users

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis	up to 3 days	participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.

Trial Locations

Locations (1)

Marmara University School of Medicine; 🇹🇷 Istanbul, Turkey