Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Marmara University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis
Study Overview
Brief Summary
Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.
Detailed Description
This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent
Exclusion Criteria
- •ones who did not sign the consent form NSAID or steroid users
Outcomes
Primary Outcomes
Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis
Time Frame: up to 3 days
participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.
Secondary Outcomes
No secondary outcomes reported
Investigators
A.Ozdemir Aktan
professor of surgery
Marmara University