Epidural vs. Wound Catheter Following Liver Resection

Not Applicable

Completed

• Conditions: Transplant Surgery
• Interventions: Procedure: This arm will received perioperative transversus abdominis plane (TAP) block followed by continuous infusion of local anaestheic by wound catheters and an IV morphine PCA.

• Registration Number: NCT03638401
• Lead Sponsor: The Leeds Teaching Hospitals NHS Trust

Brief Summary

Good postoperative pain control after any major surgery allows early mobilization, minimises postoperative complications and reduces patient distress. Multiple different methods of delivering analgesia have been described.

This study aims to compare postoperative pain control between patients with epidural analgesia versus the combination of continuous infiltration of local anaesthetic with wound catheters, TAP block and IV PCA with opiate analgesia following open liver resection. The investigators expect that pain control will be similar between the two groups but that the utilization of wound catheters will confer benefit due to the lack of systemic side effects associated with epidural analgesia

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03-03
• Study First Submitted: 2015-05-18
• Primary Completion: 2015-10-05
• Study Completion: 2015-10-05
• Status Verified: 2018-08
• Study First Submitted QC: 2018-08-16
• Last Update Submitted: 2018-08-16
• Study First Posted: 2018-08-20
• Last Update Posted: 2018-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• All adult patients scheduled to undergo an open liver resection at this hospital will be eligible to participate.

Exclusion Criteria

• Patients with a contraindication to either epidural or wound catheter
• Inability to give written, informed consent
• Aged less than 18 years old
• Liver resection combined with a secondary surgical procedure
• Body mass index of <18 or >40
• Pregnancy or lactation
• A history of chronic pain requiring regular opioid analgesia
• Prisoners

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intervention arm	This arm will received perioperative transversus abdominis plane (TAP) block followed by continuous infusion of local anaestheic by wound catheters and an IV morphine PCA.	-

Primary Outcome Measures

Name	Time	Method
The length of hospital stay following open liver resection	6 months (or length of the study)

Trial Locations

Locations (1)

Leeds Teaching Hospitals NHS Trust; 🇬🇧 Leeds, United Kingdom