The effects of grape seed extract intake on health
Not Applicable
Completed
- Conditions
- Metabolism and biological activity of oligomeric procyanidinsNot Applicable
- Registration Number
- ISRCTN39867491
- Lead Sponsor
- niversity of Milan
- Brief Summary
2023 Results article in https://pubmed.ncbi.nlm.nih.gov/38104483/ (added 18/12/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
1. Women and men
2. Aged 18-40 years
3. BMI 18-25 kg/m²
4. Healthy
5. No smokers
Exclusion Criteria
1. Smokers
2. Allergy to grape
3. Gastrointestinal disorder
4. Liver and renal disease
5. Antibiotic treatment
5. Use of supplements
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rinary excretion of oligomeric proanthocyanidin-derived human phenyl-?-valerolactone metabolite from Vitis vinifera, measured using high-resolution mass spectrometry techniques at baseline and at 1, 2, 4, 6, 10, 12, 14, 24 and 48 hours after the intervention and reported as absolute urinary concentration (nmoles/ml)
- Secondary Outcome Measures
Name Time Method 1. Lipidomic, proteomic and metabolomic status measured by using omics approaches (e.g., proteomic, lipidomic, metabolomic) in the buffy coat at baseline, after 2 hours, and 7 days post-intervention. Values will be reported semi-quantitatively as fold-change.<br>2. Levels of DNA damage in the buffy coat measured by comet assay at baseline, after 2 hours and 7 days post intervention<br>3. Levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in plasma and urine measured using ELISA kit at baseline, after 2 hours and 7 days post intervention