Comparison of local versus systemic tranexamic acid in total knee replacement
Completed
- Conditions
- Primary osteoarthritis knee
- Registration Number
- CTRI/2017/04/008401
- Lead Sponsor
- Sri Sathya Sai Institute of Higher Medical Sciences Prasanthigram
- Brief Summary
This study is intended to test for equivalence between intraarticular and intravenous routes for administration of tranexamic acid for control of perioperative blood loss in total knee replacement in terms of efficacy and safety.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 138
Inclusion Criteria
- All patients undergoing total knee arthroplasty for primary arthroplasty knee 2.Patients who are willing to participate in the study.
- 3.Patient without exclusion criteria.
Exclusion Criteria
- 1.Allergy to the TXA 2.H/O Coagulopathy,abnormal PT or APTT 3.Past H/O Thromboembolic event 4.Treatment with Aspirin or NSAIDS in the last week 5.plasma creatinine > 115 micro moles /litre for males And >100 micro moles/litre in females.
- 6.Acute infection[eg;leukocytosis or fever] 7.Malignancy 8.MI in preceding 12 months,unstable angina 9.Patient who were given plasma in perioperative period.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative Hemoglobon drop Assessed at 5 days of surgery
- Secondary Outcome Measures
Name Time Method Perioperative blood loss, need for post operative blood transfusion, impairment of renal function, occurrence of deep vein thrombosis 6 weeks
Trial Locations
- Locations (1)
Sri Sathya Sai Institute of Higher Medical Sciences - Prasanthigram
🇮🇳Anantapur, ANDHRA PRADESH, India
Sri Sathya Sai Institute of Higher Medical Sciences - Prasanthigram🇮🇳Anantapur, ANDHRA PRADESH, IndiaDr Koushik Narayan SubramanyamPrincipal investigator9491629620drkoushik@hotmail.com