Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Cerebral Blood Flow
研究概览
简要总结
Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of aSAH
- •indication to DVE positioning
- •clinical indication to sedation and assisted ventilation
- •indication to ICP and CBF monitoring
- •age > 18
排除标准
- •documented cranial hypertension (ICP>18) not controller by liquor drainage
- •age < 18.
研究组 & 干预措施
Propofol
Propofol(3-4 mg/kg/ora)administrated for 2 hours.
干预措施: Propofol (Drug)
Isoflurane
Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration
干预措施: Isoflurane (Drug)
结局指标
主要结局
Cerebral Blood Flow
时间窗: after 2 hours of drug administration
次要结局
未报告次要终点
研究者
Prof. Giuseppe Citerio
MD
Azienda Ospedaliera San Gerardo di Monza