Role of Invasive Left Heart Catheterization for Patients Suspected Heart Failure With Preserved Ejection Fraction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 404
- 试验地点
- 1
- 主要终点
- Rates of Death or re-hospitalization due to heart failure
研究概览
简要总结
Retrospectively enrolled suspicious of heart failure with preserved ejection fraction (HFpEF) patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure.
详细描述
Heart failure (HF) with preserved ejection fraction (HFpEF) remains a poorly understood clinical syndrome without effective targeted therapies. The clinical syndrome of HFpEF develops from a complex interaction of several risk factors such as aging, obesity, hypertension, myocardial ischemia, and arterial stiffness that cause organ dysfunction and, ultimately, clinical symptoms. Although the H2FPEF and HFA-PEFF scores have recently been proposed to estimate the probability of HFpEF in patients suffering from unexplained dyspnea, diagnosing HFpEF remains still challenging. The aim of the current registry was to evaluate the role of invasive left heart catheterization with the measurement of left ventricular end-diastolic pressure (LVEDP) in suspicious of HFpEF patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Left ventricular ejection fraction > 50%
- •Patients who had a symptom and/or signs of heart failure (dyspnea on exertion, chest discomfort, fatigue, dizziness, or ankle edema)
- •Patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure
排除标准
- •Left ventricular ejection fraction <50%
- •Acute coronary syndrome
- •More than moderate valvular heart disease
- •Primary cardiomyopathies such as dilated cardiomyopathy and hypertrophic cardiomyopathy, amyloidosis
- •Pulmonary arterial hypertension
- •Heart transplantation
- •Constrictive pericarditis
- •Stress-induced cardiomyopathy
结局指标
主要结局
Rates of Death or re-hospitalization due to heart failure
时间窗: 10 Years
次要结局
- Rates of All-cause death(10 Years)
- Rates of Stroke(10 Years)
- Rates of Re-hospitalization due to heart failure(10 Years)
- Rates of Myocardial infarction(10 Years)
研究者
Jeong Hoon Yang
Professor
Samsung Medical Center