Role of Invasive Left Heart Catheterization for Patients Suspected Heart Failure With Preserved Ejection Fraction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Sponsor
- Samsung Medical Center
- Enrollment
- 404
- Locations
- 1
- Primary Endpoint
- Rates of Death or re-hospitalization due to heart failure
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Retrospectively enrolled suspicious of heart failure with preserved ejection fraction (HFpEF) patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure.
Detailed Description
Heart failure (HF) with preserved ejection fraction (HFpEF) remains a poorly understood clinical syndrome without effective targeted therapies. The clinical syndrome of HFpEF develops from a complex interaction of several risk factors such as aging, obesity, hypertension, myocardial ischemia, and arterial stiffness that cause organ dysfunction and, ultimately, clinical symptoms. Although the H2FPEF and HFA-PEFF scores have recently been proposed to estimate the probability of HFpEF in patients suffering from unexplained dyspnea, diagnosing HFpEF remains still challenging. The aim of the current registry was to evaluate the role of invasive left heart catheterization with the measurement of left ventricular end-diastolic pressure (LVEDP) in suspicious of HFpEF patients.
Investigators
Jeong Hoon Yang
Professor
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •Left ventricular ejection fraction \> 50%
- •Patients who had a symptom and/or signs of heart failure (dyspnea on exertion, chest discomfort, fatigue, dizziness, or ankle edema)
- •Patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure
Exclusion Criteria
- •Left ventricular ejection fraction \<50%
- •Acute coronary syndrome
- •More than moderate valvular heart disease
- •Primary cardiomyopathies such as dilated cardiomyopathy and hypertrophic cardiomyopathy, amyloidosis
- •Pulmonary arterial hypertension
- •Heart transplantation
- •Constrictive pericarditis
- •Stress-induced cardiomyopathy
Outcomes
Primary Outcomes
Rates of Death or re-hospitalization due to heart failure
Time Frame: 10 Years
Secondary Outcomes
- Rates of All-cause death(10 Years)
- Rates of Stroke(10 Years)
- Rates of Re-hospitalization due to heart failure(10 Years)
- Rates of Myocardial infarction(10 Years)