Using Indirect Calorimetry for Liver Transplants Patients

Completed

• Conditions: Indirect Calorimetry

• Registration Number: NCT03622268
• Lead Sponsor: Asan Medical Center

Brief Summary

Although predicted REE calculated using the Penn state 1988 method agreed (ICC 0.61, p=0.00014) with the measured REE, all three predictive equations had a fixed bias and appeared to be inaccurate for predicting REE for liver transplant recipients.

Therefore, precise measurements using indirect calorimetry may be helpful when treating critically ill patients to avoid underestimating or overestimating their metabolic needs.

Detailed Description

Rationale: The aim of this study was to compare predictive equations with indirect calorimetry and identify the appropriate energy expenditure requirement of liver transplant(LT) recipients in South Korea.

Methods: This prospective observational study was conducted in a surgical ICU in an academic tertiary hospital over three months. Thirty mechanically ventilated patients who had received liver transplants and were expected to stay in the ICU more than 2 days were studied. Resting energy expenditure(REE) was measured 48 hours after ICU admission using open-circuit indirect calorimetry. Theoretical REE was estimated using three predictive equations: Harris-Benedict methods, lreton-Jones ventilated, and Penn state 1988. The REEs derived from each predictive equation were compared with the measured REE using an intraclass correlation coefficient (ICC) and a Bland-Altman plot.

Study Timeline

• Study Start: 2017-12-01
• Primary Completion: 2018-05-01
• Status Verified: 2018-08
• Study Completion: 2018-08-01
• Study First Submitted: 2018-08-03
• Study First Submitted QC: 2018-08-07
• Last Update Submitted: 2018-08-07
• Study First Posted: 2018-08-09
• Last Update Posted: 2018-08-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• mechanically ventilated patients who had received liver transplants and were expected to stay in the ICU more than 2 days were studied.

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Exclusion Criteria

• Refusal
• patients who were extubated before 36 hrs

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparing REE with the measurement for each predictive equation and indirect calorimetry	1 year	The REEs derived from each predictive equation were compared with the measured REE using an intraclass correlation coefficient (ICC) and a Bland-Altman plot.

Trial Locations

Locations (1)

Hakjae Lee; 🇰🇷 Seoul, Korea, Republic of