Nitrate - Clopidogrel - Acute Coronary Syndrome
Completed
- Conditions
- Acute Coronary Syndromes
- Registration Number
- NCT06878638
- Lead Sponsor
- Bursa Postgraduate Hospital
- Brief Summary
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- diagnosed with non-STEMI
- Patients aged 18 to 75 years
- positive troponin levels,
- blood pressure above 120/70 mmHg
Exclusion Criteria
- Hemodynamically unstable and requiring urgent intervention,
- ST elevation on electrocardiography, atrial fibrillation,
- recurrent angina,
- use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
- history of coronary artery bypass graft (CABG) surgery,
- active infection,
- uncontrolled hypertension,
- diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
- active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
- left ventricular systolic dysfunction (ejection fraction <50%),
- glomerular filtration rate <60 mL/min/1.73m2,
- allergy to ASA or clopidogrel, coagulopathy,
- platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Platelet Reactivity Unit level 48 hours Platelet Reactivity Unit \<208
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Molecular mechanisms intravenous nitrate P2Y12 receptor clopidogrel platelet inhibition NCT06878638
Comparative effectiveness intravenous nitrate vs standard antiplatelet therapy non-STEMI clopidogrel response
Biomarkers predicting clopidogrel resistance in ACS patients with concurrent nitrate administration
Adverse events intravenous nitrate-clopidogrel combination in non-STEMI patients: hypotension, bleeding risk, and management strategies
Synergistic antiplatelet approaches combining nitrates and P2Y12 inhibitors in acute coronary syndrome: tadalafil vs nitroglycerin
Trial Locations
- Locations (1)
Bursa Yüksek İhtisas Hastanesi
🇹🇷Bursa, Turkey