Bacterial Pathogens Associated With Community-acquired Pneumonia in Children

Completed

• Conditions: Children Chest Infection

• Registration Number: NCT06377163
• Lead Sponsor: Delta University for Science and Technology

Brief Summary

Pediatric community acquired pneumonia (CAP) is one of the most common reasons for hospital admission, there is no reliable way of distinguishing the causative organism based on clinical features.

This study examined common pathogens of community-acquired pneumonia from 28 days up to 10 years in Dakahlia Governorate.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2021-08-31
• Study Completion: 2021-08-31
• Study First Submitted: 2024-04-10
• Study First Submitted QC: 2024-04-18
• Study First Posted: 2024-04-22
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-09
• Last Update Posted: 2024-06-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastric lavage culture or sputum culture on admission	At the baseline evaluation	It was inserted through the nose and down the stomach after nebulization with hypertonic saline at 5% for 10 seconds. Suction was applied for up to 15 seconds to collect the swallowed sputum in a sterile container. A culture was considered positive if any organism was identified.
Complete blood count	At the baseline evaluation	From each participant, a sample of 4 ml of fresh venous blood was collected from the peripheral vein by the sterile venipuncture technique \& drawn into a vacuumed purple top tube containing an anticoagulant. It was performed using a fully automated hematology analyzer. This test measures the amounts and sizes of red blood cells, hemoglobin, white blood cells, and platelets. It will be aggregated to arrive at one report. Hemoglobin is usually reported in units of grams per liter, or grams per deciliter. The analyzer counts red blood cells, reporting the result in units of 106 cells per microliter of blood or 1012 cells per liter, and measures their average size, which is called the mean cell volume and expressed in femtoliters or cubic micrometers. The total white blood cell count is usually reported in cells per microliter of blood, or 109 cells per liter. The platelet count can be reported in units of cells per microliter of blood, 103 cells per microliter, or 109 cells per liter.
C-reactive protein (CRP)	At the baseline evaluation	It was measured quantitatively in human serum by Beckman-Coulter AU Analyzers (USA).; Sample preparation: 2 ml of blood in a sterile tube was centrifuged, then used immediately for CRP. C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma whose circulating concentrations rise in response to inflammation. Traditional CRP measurement only detected CRP in the range of 10 to 1,000 mg/L, whereas high-sensitivity CRP (hs-CRP) detects CRP in the range of 0.5 to 10 mg/L.
Blood culture and sensitivity on admission	At the baseline evaluation	It was done using the BD Bactec 9050 Blood Culture System (USA, Catalog No. 445800) instrument. A culture was considered positive if any organism was identified.

Trial Locations

Locations (1)

Amira Hussin Mohammed; 🇪🇬 Gamasa, Egypt