The Role of Vitamin A in Brown Fat Activity and Energy Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Correlation between retinol/retinol-binding protein concentrations and cold-induced brown fat acitivity
研究概览
简要总结
Vitamin A metabolites (retinoids) have shown to activate brown fat function in preclinical studies, however the role of retinoids in human brown fat physiology and energy metabolism remains elusive. This study aims to identify a possible association between retinoid metabolism, brown fat activity, and energy expenditure in lean and obese subjects by using FDG-PET-CT, PET-MR Scans and indirect calorimetry. Additionally we will analyze the genetic profile of white and brown neck fat biopsies at room temperature and cold conditions in a subset of the study participants. More detailed molecular studies (involving other potential browning markers) will also be performed in adipocytes derived from human SVC.
The optimal duration of cold exposure will be determined in a pilot study. Therefore subjects will be repeatedly exposed to cold and circulating retinoid levels and other plasma parameters will be measured at various time points.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 20 - 45 years.
- •Body mass index (BMI) 18.5 - 24.9 kg/m2 (lean) or 30.0 - 38.0 kg/m2 (obese)
排除标准
- •Endocrine (except hyperlipidemia), cardiovascular (except hypertension), liver, kidney, inflammatory bowel, rheumatic, oncologic disease or any other chronic condition.
- •Medication for any of the above mentioned conditions.
- •Pregnancy
- •Metallic implants that are not MRI compatible
研究组 & 干预措施
Obese
Cold exposure
干预措施: Cold exposure (Other)
Lean
Cold exposure
干预措施: Cold exposure (Other)
结局指标
主要结局
Correlation between retinol/retinol-binding protein concentrations and cold-induced brown fat acitivity
时间窗: 6 years
A possible association between serum retinol and retinol-binding protein concentrations and cold-induced brown fat activity in lean and obese subjects, respectively, will be analyzed.
次要结局
- Analyses of potential BAT or browning markers in humans(6 years)
- Identification of new factors related to brown fat function(6 years)
- Association between BAT activity and energy expenditure(6 years)
研究者
Dr. Florian Kiefer
MD, PhD
Medical University of Vienna