The long-term effects of Small Vessel Disease
Completed
- Conditions
- Cerebral vasculopathy - White matter hyperintensities100422581000984110003216
- Registration Number
- NL-OMON48199
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 250
Inclusion Criteria
Participants alive of the RUN DMC cohort (cohort of patients with small vessel disease)
• In such a condition allowing to visit the research centre
• Written informed consent
Exclusion Criteria
- (Psychiatric) disease interfering with cognitive testing or follow-up
- Contra-indications to MR Imaging
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The SVD neuroimaging markers, incidence of vascular events, dementia and<br /><br>parkinsonism. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Change in cognitive function<br /><br>- Severity of BBB dysfunction, based on quantitative pharmacokinetic parameter<br /><br>values</p><br>