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临床试验/NCT03807791
NCT03807791已完成不适用

Study of Prevalence and Risk Factors of Hypovitaminosis C in Long Term Care Unit

Hospices Civils de Lyon2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2019年1月31日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
2
主要终点
Vitamin C plasma level

研究概览

简要总结

The clinical finding of skin rashes which appear after a vitamin C deficiency in Long Term Care Unit leads us to believe that the institutional diet could predispose to this kind of deficiency. Vitamin C has a key role into the struggle against oxidant stress and is involved into the connective tissue formation of the skin and the vascular endothelium. Vitamin C deficiency affects currently 15 to 25% of the elderly over 65 years old reaching 15% women and 20% men after 65 according to Johnston and Al. It concerns mainly the people in precarious situations (persons without fixed homes, ethyl-smoking persons) and elderly over 65 years. Hypovitaminosis C, defined by plasma level between 5 mg/L and 15 mg/L (28.41 to 85.23 µmol/L), is currently undiagnosed, especially with people with a risk of food deficiency and its prevalence increases with age. The treatment consists of a daily oral supplementation of 1 gram of vitamin C/d for 15 days. A minimum intake of 10 mg/D of vitamin C is required to prevent scurvy and maintain a total pool of 350 mg. A diet modification by a systematic intake of 2 glasses of fresh orange juice and/or the consumption of raw fruits and vegetables would prevent the appearance of scurvy.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Prevention
盲法
None

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Male or female over 65 years old
  • living in the Unit of Long Term Care without any limit time.
  • with a system of social insurance
  • Who gave its consent by his own , or with help of his representant or his tutor or curator.

排除标准

  • rejection of the blood sample
  • patient feeding with articial nutritional feeding (stomach tube feeding)
  • person close to death, who is not able to feed himself and / or with life-threatening in short time.
  • Patient with personal history of vitamin C deficiency.

研究组 & 干预措施

Patient living in the Unit of Long Term Care

Experimental

Patient living in the Unit of Long Term Care without any limit time

干预措施: Blood sample (Procedure)

结局指标

主要结局

Vitamin C plasma level

时间窗: Between day 0 and day 7.

1. ) Collection of the consent 2. ) At the same time as other analysis for current cares a blood sample taken by a nurse of our unit to determine plasma levels of vitamin C. 3. ) Registration of risk factors of vitamin C deficiency. . 4. ) Doing a clinical exam within 7 days after the blood sample.

次要结局

  • Cutaneous symptoms(Day 0)
  • Supposed risk factors of hypovitaminosis C(Day 0)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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