Evaluation of arthrosis of knee repair by stem cells
Phase 1
- Conditions
- Osteoarthrithis.Unspecified osteoarthritisM19.90
- Registration Number
- IRCT2015072523342N1
- Lead Sponsor
- East Azarbaijan science and technology park
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Inclusion Criteria: Persons between 45 and 60 year old; Radiological Classification: Kellgren-Lawrence scale greater or equal to 2; Body mass index greater than 30kg/m2; Ability to follow during the study period
Exclusion Criteria
Grater osteoarthritis Grad than 2; Previous chondral surgury; Patients with diabetes mellitus, systemic lupus erythematosus, hepatitis, HIV , malignancy, Alzheimer, addiction to opioids; Treatment with growth factor in the 1 months prior to inclusion in the study; Patients with a history of septicemia, viral or fungal infection; History of radiotheraphy; Patients with long term contact with poisonous compounds
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increasing of articular cartilage thickness of knee and repair tissue over subchondral bone in MRI. Timepoint: Before treatment and 6 months after treatment. Method of measurement: MRI scaling.;Pain severity. Timepoint: Before treatment and two weeks, 1, 3 and 6 months after treatment. Method of measurement: Lequesne index for pain.
- Secondary Outcome Measures
Name Time Method Knee joint function by WOMAC index. Timepoint: Before treatment and two weeks, 1, 3 and 6 months after tratment. Method of measurement: WOMAC index.