Airways Management in COVID-19 Related Respiratory Failure: a Prospective Observational Multi-center Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19 Pneumonia
- Sponsor
- St. Bortolo Hospital
- Enrollment
- 143
- Locations
- 2
- Primary Endpoint
- Major adverse peri-intubation events
- Last Updated
- 4 years ago
Overview
Brief Summary
The Emergency Endotracheal intubation of a patient who is COVID-19 positive is a high-risk procedure and an additional challenge to an intensivist due to barrier enclosures that have been developed to reduce the risk of COVID-19 transmission to healthcare providers during intubation. Although the incidence of difficult airways is commonly higher in critically ill patients, the evidence of severe hypoxemia without sign of respiratory distress could complicate the scenario.This silent hypoxia often leads to a delayed recognition of the severity of respiratory failure and to a late intubation which is often characterized by a high risk of complications related to the actual airways' management, hemodynamic and cardiac. It has been shown that non-survivors had worse blood gas analyzes than survivors, both before and after intubation. Few studies have reported the implications and adverse events of performing endotracheal intubation for critically ill COVID-19 patients admitted to intensive care units (ICUs).
Investigators
Silvia De Rosa
Principal Investigator
St. Bortolo Hospital
Eligibility Criteria
Inclusion Criteria
- •Critically ill patient above 18 year old, admitted in the Intensive Care of San Bortolo Hospital, Vicenza, and San Matteo Hospital, Pavia;
- •positive specimen for SARS-COV2 PCR;
- •tracheal intubation for respiratory distress related to SARS COV2 pneumonia
Exclusion Criteria
- •negative specimen for SARS-COV2 PCR
- •out of hospital intubation
- •intubation during cardiac arrest
- •intubation in the contest of general anesthesia for surgery
Outcomes
Primary Outcomes
Major adverse peri-intubation events
Time Frame: intubation procedure, an expected average 30 minutes
The incidence of major adverse peri-intubation events defined as least one events: * cardiovascular instability * severe Hypoxemia * cardiac arrest
Secondary Outcomes
- Number of minor complications in the intubation process in patients admitted in the intensive care(28 days)
- Correlation between videolaryngoscope use and incidence of complication compared to the conventional laryngoscopy(28 days)