Salivary Proteomic Comparison of Oral Lichen Planus and Oral Leukoplakia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Quantitative differences in salivary protein expression profiles between OLP, OL, and healthy control groups measured using label-free nLC-MS/MS proteomic analysis.
研究概览
简要总结
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease. The main questions it aims to answer are:
- Do salivary protein expression patterns differ between patients with OLP, OL, and healthy controls?
- Can specific differentially expressed proteins serve as potential biomarkers for distinguishing OLP and OL from each other and from healthy individuals?
Researchers will compare salivary proteomic profiles from patients with OLP, patients with OL, and healthy controls to determine whether measurable differences in protein expression exist between the groups. Participants will:
- Provide unstimulated saliva samples collected as part of the study protocol.
- Undergo grouping based on clinical diagnosis (OLP, OL, or healthy control), after which samples will be pooled and analyzed using nano-liquid chromatography coupled with tandem mass spectrometry (nLC-MS/MS) and label-free protein quantification methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 29 Years 至 71 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Saliva samples from patients diagnosed with either OLP or OL were included in the study group.
- •Saliva samples from individuals with no dermatological or systemic diseases and no lesions in the oral mucosa were included in the control group.
排除标准
- •Patients who were using corticosteroids or retinoids that could affect the mucosa either locally or systemically were excluded from the study.
- •Patients with hyposalivation or with any conditions or medications that could cause reduced salivary flow were also excluded from the study.
研究组 & 干预措施
Oral Lichen Planus
Oral Leukoplakia
Control Patients with Healthy Oral Mucosa
结局指标
主要结局
Quantitative differences in salivary protein expression profiles between OLP, OL, and healthy control groups measured using label-free nLC-MS/MS proteomic analysis.
时间窗: Baseline (single study visit during saliva sample collection; no longitudinal follow-up)
次要结局
未报告次要终点
研究者
Alican Kuran
Assistant Professor
Kocaeli University