JPRN-UMIN000031501已完成未知
A phase I study Afatinib in Combination of Osimertinib in patients with Relapsed Non-Small Cell Lung Cancer after failure of prior Osimertinib - A phase I study Afatinib in Combination of Osimertinib in patients with Relapsed Non-Small Cell Lung Cancer after failure of prior Osimertinib
iigata Cancer Center Hospital0 个研究点目标入组 20 人开始时间: 2018年3月9日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Patients who are difficult to treat enrolled doses due to toxicity of afatinib 2) History of drug-induced pneumonitis, Interstitial pneumonia 3) Symptomatic brain metastasis, leptomeningitis 4) Bone metastasis to treat by operation or radiation therapy 5) Uncontrollable pleural, peritoneal or pericardial effusion 6) Prior thoracic palliative radiotherapy within 2wks 7) SCLC transformation 8) History of active double cancer 9) Severe infection 10) Active HBV infection 11) No intention to birth control 12) Unstable psychic disorder 13) Under treatment of steroid therapy or immunosuppressive therapy 14) History of allergic reaction 15) Decision of ineligibility by a physician
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