The effect of Inulin prebiotic supplementation (inulin or Oligofructose-enriched inulin) on type2 diabetic patients
Not Applicable
- Conditions
- diabetes.Endocrine, nutritional and metabolic diseases
- Registration Number
- IRCT201110293253N4
- Lead Sponsor
- Health and Nutrition Faculty, Tabriz University of Medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 66
Inclusion Criteria
age 30-65 years old, 25= BMI <35, having diabetes at least 6 months prior to the study, consumption of blood glucose lowering drug,. typical ?ber intake <25 g ?ber/d and inulin fructans intake =200 g ?ber/d.
Exclusion criteria: consumption of antioxidants supplements during last 3 months prior to the study, using insulin, pregnancy, lactation, acute renal disease
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dietary intake. Timepoint: 8 weeks. Method of measurement: 24 hours-food recal questionnaire.;Serum antioxidant status. Timepoint: 8 weeks. Method of measurement: measurement of SOD,GPX-H,TAC,MDA.;Total grelin level. Timepoint: 8 weeks. Method of measurement: Serum level of fasting total grelin.;Lipid profiles. Timepoint: 8 weeks. Method of measurement: TC, TG, LDL, HDL.;Insulin level. Timepoint: 8 weeks. Method of measurement: Serum level of fasting insulin.;Blood glucose & HbA1c. Timepoint: 8 weeks. Method of measurement: fasting blood glucose & HbA1c.;Inflammatory factors. Timepoint: 8 weeks. Method of measurement: HS-CRP,TNF-a,IL-6,IFN-?.;Anti-Inflammatory factor. Timepoint: 8 weeks. Method of measurement: IL-10.
- Secondary Outcome Measures
Name Time Method Anthropomethric indices. Timepoint: 8 weeks. Method of measurement: Weight, Height, BMI.WB,WHR.;Appetite. Timepoint: 8 weeks. Method of measurement: questionnaire.;Lipopolysaccharide. Timepoint: 8 weeks. Method of measurement: serum Lipopolysaccharide.;Blood pressure. Timepoint: 8 weeks. Method of measurement: blood pressure.