Chiropractic T Cell Study

Not Applicable

Completed

• Conditions: Intervention; Waitlist Control
• Interventions: Procedure: full spine corrective protocol

• Registration Number: NCT05412602
• Lead Sponsor: University of British Columbia

Brief Summary

Some studies suggest that specific chiropractic care (techniques known as "spinal manipulation therapy") can have benefits to the immune system but studies are scarce, sample sizes small, and methodology and analyses often not of the highest scientific standards. The investigators will example how 36 sessions of chiropractic care over 9-12 weeks can impact immune cell function using a randomized clinical trial design.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-06-06
• Study First Submitted QC: 2022-06-06
• Study First Posted: 2022-06-09
• Study Start: 2022-07-25
• Primary Completion: 2023-09-01
• Study Completion: 2023-12-31
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-05
• Last Update Posted: 2025-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Must be between the ages of 18-70.
• Must exhibit vertebral subluxation as measured by a misalignment between one or more vertebrae in relation to normal spinal alignment.
• Have not been sick for the past 3 weeks (immune function).
• Non-smoker.
• Must be able to fast for 10-12 hours.

Exclusion Criteria

• To have had a chiropractic intervention within the past 6 months.
• To have a condition that may limit the ability to apply a high velocity, low amplitude (HVLA) thrust to the spine such as but not limited to ligament damage, reduced bone density, or other factors that weaken the body's ability to withstand reasonable care (bone cancer, fractures, osteoporosis, etc.)
• To have excessive scoliotic curvature of the spine (> 30º) as measured by identifying the first vertebrae, and the most laterally displaced vertebrae that exhibits tilt below it.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	full spine corrective protocol	experimental group will receive 36 chiropractic treatments designed to correct vertebral subluxation over \~12 weeks

Primary Outcome Measures

Name	Time	Method
Change in CD25+ Regulatory T Cell	12 weeks	CD25+ Regulatory T Cell count will be measured by surface staining using flow cytometry

Secondary Outcome Measures

Name	Time	Method
Change in CD4+ and CD8+ T cell	12 weeks	CD4+ and CD8+ T cell count measured by surface staining using flow cytometry

Trial Locations

Locations (1)

University of British Columbia Okanagan; 🇨🇦 Kelowna, British Columbia, Canada