Impact of a Corrective Model of Chiropractic Care on Immune Cell Phenotype and Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Change in CD25+ Regulatory T Cell
研究概览
简要总结
Some studies suggest that specific chiropractic care (techniques known as "spinal manipulation therapy") can have benefits to the immune system but studies are scarce, sample sizes small, and methodology and analyses often not of the highest scientific standards. The investigators will example how 36 sessions of chiropractic care over 9-12 weeks can impact immune cell function using a randomized clinical trial design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be between the ages of 18-
- •Must exhibit vertebral subluxation as measured by a misalignment between one or more vertebrae in relation to normal spinal alignment.
- •Have not been sick for the past 3 weeks (immune function).
- •Non-smoker.
- •Must be able to fast for 10-12 hours.
排除标准
- •To have had a chiropractic intervention within the past 6 months.
- •To have a condition that may limit the ability to apply a high velocity, low amplitude (HVLA) thrust to the spine such as but not limited to ligament damage, reduced bone density, or other factors that weaken the body's ability to withstand reasonable care (bone cancer, fractures, osteoporosis, etc.)
- •To have excessive scoliotic curvature of the spine (> 30º) as measured by identifying the first vertebrae, and the most laterally displaced vertebrae that exhibits tilt below it.
研究组 & 干预措施
Intervention
experimental group will receive 36 chiropractic treatments designed to correct vertebral subluxation over ~12 weeks
干预措施: full spine corrective protocol (Procedure)
waitlist control
waitlist control will receive no chiropractic interventions and will be reminded that to successfully complete their condition, they do not seek alternative chiropractic treatments
结局指标
主要结局
Change in CD25+ Regulatory T Cell
时间窗: 12 weeks
CD25+ Regulatory T Cell count will be measured by surface staining using flow cytometry
次要结局
- Change in CD4+ and CD8+ T cell(12 weeks)
研究者
Jonathan Little
Associate Professor
University of British Columbia