The Effect of ß-glucan Prebiotic Fibre (Oats) on the Gut Microbiome of Chronic Kidney Disease Patients (Stage IV and V) and Impact on Kidney Function.

o sponsors0 个研究点目标入组 70 人开始时间: 2020年2月11日最近更新: 2023年5月29日

适应症

试验速览

Results will be reported as per outcome statistical summary in the document below

•Patients with CKD stage 4 (GFR 15-29 ml/min) and 5 (GFR<15 ml/min) pre-dialysis patients attending the Tygerberg Renal Outpatient Clinic.
•Patients have to be 18 years or older and able to give informed written consent.

•Patients on antibiotics, prebiotics or probiotic supplements currently or in the past 4 weeks.
•Patients with inflammatory bowel disease, bowel malignancy, previous colorectal surgery (or any other serious bowel disorder)
•Pregnancy, diabetes mellitus, coeliac disease, human immunodeficiency virus (HIV) disease, malignant hypertension, crescentic glomerular nephritis
•Patients on immunosuppressant medications.
•CKD patients who are expected to start dialysis within the next 2 months will be excluded.
•The conditions mentioned above are excluded due to it influencing either the gut microbiome or renal outcomes.

发起方

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