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Clinical Trials/2024-518949-14-00
2024-518949-14-00RecruitingPhase 2

Beta-blockade with landiolol in out-of-hospital cardiac arrest: a randomized, double-blind, placebo-controlled, pilot trial

Medical University Of Vienna1 site in 1 country48 target enrollmentStarted: December 10, 2024Last updated:
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Conditions
Drugs

Trial Snapshot

Phase
Phase 2
Status
Recruiting
Enrollment
48
Locations
1
Primary Endpoint
Time (in minutes) to sustained return of spontaneous circulation
Study OverviewEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

To demonstrate that add-on treatment with landiolol in patients with cardiac arrest significantly decreases the time to sustained ROSC (sROSC) (time from infusion of study medication to sustained ROSC)

Eligibility Criteria

Ages
18 years to 65+ years (18-64 Years, 65+ Years)
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •OHCA , ³ 18 years of age • 3 or more shockable rhythms (VF or pVT) and last rhythm shockable

Exclusion Criteria

  • •Age > 85a • Severe head trauma or acute active bleeding • Known allergy or insensitivity to landiolol or another b-blocker

Outcomes

Primary Outcomes

Time (in minutes) to sustained return of spontaneous circulation

Time (in minutes) to sustained return of spontaneous circulation

Secondary Outcomes

  • cummulative ROSC, temporary ROSC, sustained ROSC, survival at 24h, favorable neurologic outcome

Investigators

Sponsor Class
Educational Institution
Responsible Party
Principal Investigator
Principal Investigator

Department of Clinical Pharmacology

Scientific

Medical University Of Vienna

Study Sites (1)

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