Physiologic MR Imaging of Salivary Gland Tumors
- Conditions
- Salivary Gland Tumor
- Interventions
- Diagnostic Test: MRI
- Registration Number
- NCT04452162
- Lead Sponsor
- Abramson Cancer Center at Penn Medicine
- Brief Summary
The goal of this study is to use advanced Magnetic Resonance Imaging (MRI) techniques to help identify the difference between cancerous and non-cancerous salivary gland tumors for improving treatment strategies and to aid in the prediction of disease progression.
- Detailed Description
The goal of this proposed study is to investigate the potential utility of combined analysis of parameters (Ktrans, ti and ADC) in discriminating benign from malignant salivary glands tumors (SGTs). A total of 30 treatment naïve patients suspicious of SGT as observed on clinical evaluation and prior routine CT, MRI, Ultrasound, FNAC and/or PET will undergo 3T MRI. The MRI protocol will include acquisition of anatomical images with and without contrast agent injection, diffusion imaging and dynamic contrast enhanced-MRI.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
- Possess a salivary gland lesion of 1cm3 size
- Have no prior history of treatment for salivary gland lesion
- Has any prior history of cancer other than SGT
- Has any MRI contra-indications
- Has a history of known renal disease.
- Has history of prior radiation to head and neck region
- Is pregnant
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Salivary Gland Tumor MRI -
- Primary Outcome Measures
Name Time Method Differentiation and Progression Free 6 Month after the end of treatment Differentiation of malignant from benign neoplasms and progression free survival at 6 month starting from end of chemo-radiation treatment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States