Evaluation Of comparative efficacy of newly developed Kinshuk gel versus active control compound (Heparin Sodium plus Benzyl Nicotinate in the management of Thrombophlebitis (Sira Granthi Vikar) (RCT)

Thrombophlebitis is defined1 as formation of blood clot inside the vein resulting inflammation of adjacent tissue of wall. it Also known as phlebothrombosis or venous thrombosis.1 Pathophysiological causes include presence of a thrombus in the lumen of a superficial vein, followed by Inflammatory reaction of its wall and adjacent tissue. It precedes thrombophlebitis is initiated by triad of changes: endothelial damage, alteration in the composition of blood and venous stasis. It represents as swelling, tenderness, redness etc. there is bruises, blood clot under the skin also may be seen. in 1856 Virchow identified three predisposing factors – slowing of blood stream, changes in blood vessel wall, changes in blood itself. Also called as Virchow’s Triad Those who are immobile after surgery, obese, having varicose veins etc. it happens by trauma to vein. With various external injury or internal factors. Here the major cause of superficial thrombophlebitis is by venous injury like intra venous catheter, intra venous injection etc. there are 3 types of phlebitis mainly mechanical, chemical, infectious. Mechanical thrombophlebitis occurs when peripheral IV catheter not secured properly leading tissue damage. In Chemical phlebitis occur by irritants like drugs, infectious thrombophlebitis produced when using contaminated catheter during Iv insertion. Among them there is 30% cases 2 involving IV cannula linked thrombophlebitis. Thrombophlebitis migrates in which multiple thrombus appears in superficial vein and although deeper can be involved. Some other factor like secondary infection, bacteremia etc. in which circulating organism settle in intima of vein and produce phlebitis with secondary thrombosis. Here the major cause ofsuperficial thrombophlebitis is by venous injury like intra venous catheter, intra venous injection etc. For superficial thrombophlebitis topical Heparin is used with Benzyle nicotinate topically for 7 days duration. 2 In view of ayurveda thrombophlebitis can be corelate with siragat vikar, As siragranthi 3. Sira granthi explained by Aacharya Sushrut in Nidan sthan as type of granthi. Which is caused by vatadi dosha dushti, mamsa and asruk dushti. In samprapti bhedan vyayam aadi nidan sevan cause vat dushti which cause sirapratan, sira sampidan, sira sankoch, sira vishoshan and in results vrut & aashu sira granthi appears. Sira is updhatu of rakta dhatu. Sira genesis done by essence part of rakta dhatu. In thrombophlebitis there is raktavaha dushti and siragat vikar. In correlation blood clot may be shonit sanghat in sira.