Functional Imaging With Computational Fluid Dynamics to Evaluate the Airways in Patients With Acute Lung Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ARDS, Human
- Sponsor
- University Hospital, Antwerp
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Regional bronchial recruitment
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
This is a prospective single-center cohort trial to compare regional bronchial recruitment, bronchial distention and alveolar recruitment in 6 patients with acute respiratory distress syndrome (ARDS). The investigators used CT scan images as the imaging modality, and the subjects were scanned on end-expiratory lung volume with different positive end-expiratory pressures. Those images were post-processed to evaluate the airways.
Investigators
Tom Schepens, MD
Research fellow
University Hospital, Antwerp
Eligibility Criteria
Inclusion Criteria
- •mechanically ventilated
- •moderate or severe ARDS, as defined by the Berlin criteria
Exclusion Criteria
- •pregnancy
- •hemodynamic instability
- •obesity (BMI \>30)
Outcomes
Primary Outcomes
Regional bronchial recruitment
Time Frame: Through study completion, within 24 hours after inclusion
The difference in bronchial tree volume increase from one PEEP level to the other
Regional bronchial dilation
Time Frame: Through study completion, within 24 hours after inclusion
The difference in bronchial diameter from one PEEP level to the other
Regional alveolar recruitment
Time Frame: Through study completion, within 24 hours after inclusion
The difference in alveolar volume from one PEEP level to the other
Secondary Outcomes
- Correlation between parenchymal recruitment and bronchial recruitment(Through study completion, within 24 hours after inclusion)