Functional Imaging With Computational Fluid Dynamics to Evaluate the Airways in Patients With Acute Lung Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Regional bronchial recruitment
研究概览
简要总结
This is a prospective single-center cohort trial to compare regional bronchial recruitment, bronchial distention and alveolar recruitment in 6 patients with acute respiratory distress syndrome (ARDS). The investigators used CT scan images as the imaging modality, and the subjects were scanned on end-expiratory lung volume with different positive end-expiratory pressures. Those images were post-processed to evaluate the airways.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mechanically ventilated
- •moderate or severe ARDS, as defined by the Berlin criteria
排除标准
- •pregnancy
- •hemodynamic instability
- •obesity (BMI >30)
研究组 & 干预措施
Single arm
Repeated CT scan
干预措施: Repeated CT scan (Procedure)
Single arm
Repeated CT scan
干预措施: CT scan (Device)
结局指标
主要结局
Regional bronchial recruitment
时间窗: Through study completion, within 24 hours after inclusion
The difference in bronchial tree volume increase from one PEEP level to the other
Regional bronchial dilation
时间窗: Through study completion, within 24 hours after inclusion
The difference in bronchial diameter from one PEEP level to the other
Regional alveolar recruitment
时间窗: Through study completion, within 24 hours after inclusion
The difference in alveolar volume from one PEEP level to the other
次要结局
- Correlation between parenchymal recruitment and bronchial recruitment(Through study completion, within 24 hours after inclusion)
研究者
Tom Schepens, MD
Research fellow
University Hospital, Antwerp