Efficacy and Mechanisms of Acupuncture for Patients With Advanced Pancreatic Cancer Pain: : a Randomized, Placebo Controlled Trial
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Pain scores, assessed with numeric rating scale (NRS)
研究概览
简要总结
This study compares the effect of acupuncture and placebo acupuncture on advanced pancreatic cancer pain and then investigates its potential mechanism of peripheral blood.
详细描述
Acupuncture may alleviate abdominal or back pain of patients with advanced pancreatic cancer. Acupuncture participants would receive electroacupuncture on Jiaji (Ex-B2) points for 3 times in a week. Placebo acupuncture participants would receive placebo acupuncture on non-point points for the same period. Pain scores on numeric rating scale (NRS) and blood levels of β-endorphin and nerve growth factor are compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Advanced pancreatic cancer at Ⅲ-Ⅳ stage diagnosed by histological/cytological examination.
- •Pain score of abdominal or back pain ≥3 on a numeric rating scale (NRS) graduated from 0 to
- •Stable dose of analgesics at least 72 hours before randomization.
- •Expected survival time more than 1 month.
排除标准
- •Another cause for abdominal or back pain (such as prolapse of lumbar intervertebral disc, ulcer or other intra-abdominal disorder).
- •Acupuncture treatment in the past.
- •Contraindications for the use of acupuncture (such as severe allergies, bleeding tendency, infectious dermatosis and ulcer or scar at points).
- •Unable to give informed consent.
研究组 & 干预措施
Acupuncture
Acupuncture participants would receive electroacupuncture on Jiaji (Ex-B2) points for 3 times in a week.
干预措施: Acupuncture (Device)
Placebo acupuncture
Placebo acupuncture participants would receive placebo acupuncture on non-point points for the same period.
干预措施: Placebo acupuncture (Device)
结局指标
主要结局
Pain scores, assessed with numeric rating scale (NRS)
时间窗: 1 week
次要结局
- Blood levels of β-endorphin(1 week)
- Karnofsky performance status (KPS) score(1 week)
- Blood levels of nerve growth factor(1 week)