Is post-ictal EEG suppression (PGES) in epilepsy caused by excessive cortical inhibition?<br>Pilot study
Recruiting
- Conditions
- Epilepsyseizures10039911
- Registration Number
- NL-OMON47409
- Lead Sponsor
- Stichting Epilepsie Instellingen Nederland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
Cases
- Aged 18 years or over
- Frequent convulsive seizures (*1 per 12 months)
- Recurring nocturnal seizures
Controls
- Aged 18 years or over
- No epilepsy
Exclusion Criteria
Cases and controls
- Pregnancy
- Use or medication other than anti-epileptic drugs that alter cortical excitability (b-blockers)
- performance IQ <80
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>TMS measures of cortical excitability (Motor threshold, Motor evoked potential<br /><br>amplitude, cortical silent period, short and long recovery curves).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Serum levels of anti-epileptic medication</p><br>