Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?

Not Applicable

Terminated

• Conditions: Insulin Resistance
• Interventions: Other: Wingate HIT; Other: Modified HIT; Other: High-fat overfeeding

• Registration Number: NCT02177604
• Lead Sponsor: University of Adelaide

Brief Summary

Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-06-19
• Study First Submitted QC: 2014-06-25
• Study First Posted: 2014-06-27
• Study Start: 2014-11
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-23
• Last Update Posted: 2018-05-25

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 7

Inclusion Criteria

• Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week)
• Overweight (BMI 25-29.9 kg/m2)

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Exclusion Criteria

• Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.)
• History of chest pain (either at rest or during exercise.)
• Abnormal resting ECG at screening visit
• Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.)
• Blood pressure or blood lipids outside of reference ranges
• Serum ferritin <30ng/mL
• Uncontrolled asthma, current fever, or upper respiratory infection
• Current intake of > 140g alcohol/week
• Current smokers of cigarettes/cigars/marijuana
• Current intake of any illicit substance
• Experience claustrophobia in confined spaces
• Donated blood in the past 3 months
• Migraines
• Unable to comprehend study protocol
• Unable to perform exercise on a cycle ergometer at second screening visit

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Wingate HIT	Wingate HIT	7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.
Modified HIT	Modified HIT	7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training
No Exercise Control	High-fat overfeeding	7 days of high-fat overfeeding (50% excess calories) with no supervised exercise
Wingate HIT	High-fat overfeeding	7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.
Modified HIT	High-fat overfeeding	7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training

Primary Outcome Measures

Name	Time	Method
Change in glucose metabolism	1 week	Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test.

Secondary Outcome Measures

Name	Time	Method
Change in plasma levels of cytokines	1 week	Change in plasma levels of adiponectin, irisin, sex hormone-binding globulin and c-reactive protein

Trial Locations

Locations (1)

South Australian Health & Medical Research Institute; 🇦🇺 Adelaide, South Australia, Australia