Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Change in glucose metabolism
研究概览
简要总结
Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week)
- •Overweight (BMI 25-29.9 kg/m2)
排除标准
- •Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.)
- •History of chest pain (either at rest or during exercise.)
- •Abnormal resting ECG at screening visit
- •Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.)
- •Blood pressure or blood lipids outside of reference ranges
- •Serum ferritin <30ng/mL
- •Uncontrolled asthma, current fever, or upper respiratory infection
- •Current intake of > 140g alcohol/week
- •Current smokers of cigarettes/cigars/marijuana
- •Current intake of any illicit substance
- •Experience claustrophobia in confined spaces
- •Donated blood in the past 3 months
- •Migraines
- •Unable to comprehend study protocol
- •Unable to perform exercise on a cycle ergometer at second screening visit
研究组 & 干预措施
Wingate HIT
7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.
干预措施: Wingate HIT (Other)
Wingate HIT
7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.
干预措施: High-fat overfeeding (Other)
Modified HIT
7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training
干预措施: Modified HIT (Other)
Modified HIT
7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training
干预措施: High-fat overfeeding (Other)
No Exercise Control
7 days of high-fat overfeeding (50% excess calories) with no supervised exercise
干预措施: High-fat overfeeding (Other)
结局指标
主要结局
Change in glucose metabolism
时间窗: 1 week
Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test.
次要结局
- Change in plasma levels of cytokines(1 week)
研究者
A/Prof Leonie Heilbronn
Associate Professor
University of Adelaide